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Old 03-02-2005, 04:58 PM
USCDiver USCDiver is offline
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Join Date: Apr 2000
Location: NC
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I'm going to try to recall my microbiology from 3 years ago here.... (basics: antigen is the protein on the virus that illicits an immune response; antibody is what the body produces to enable it to recognize and eliminate future exposures to antigen)

The HBV vaccine consists of HBV surface antigen (HBs) which the body produces an immunologic response to, generating anti-HBsAb (antibody).

Infection with HBV exposes the person to both the surface antigen and the core antigen resulting in both anti-HBsAb and anti-HBcAb. The vaccine contains no core antigens (it is not a live virus immunization), hence it is impossible to have Anti-HBcAb without infection.