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  #1  
Old 03-16-2002, 09:24 PM
Mephisto Mephisto is offline
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What's The Most Powerful Narcotic?

I'm wondering which drugs out there are the most powerful pain-killers, legal or otherwise. Morphine is the strongest drug I've seen used for pain (after abdominal surgery); is there anything stronger/more effective?

Ideally, I'd like somebody to say, "Well, according to my professors at med school, X is the most potent drug known to science." I've been unable to find anything really good along these lines on the net--maybe I've been looking in the wrong places.

Let me say that this isn't a search for medical advice, nor do I want to engage in a "I-like-to-get-stoned-on-this-drug" conversation. This is a serious question and I don't want to see this thread get locked or deleted or anything.

Thanks in advance people!

Notice how I avoided making any bad "Straight Dope" puns . . .
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  #2  
Old 03-16-2002, 11:21 PM
KarlGauss KarlGauss is offline
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Of those narcotics available on prescription, Fentanyl (Sublimaze) is the most potent on a milligram for milligram basis. Here is a chart comparing equivalent analgesic doses.
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  #3  
Old 03-16-2002, 11:33 PM
Dragonblink Dragonblink is offline
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Keep in mind that narcotics, like all drugs, affect different people differently. I'm sure morphine, for instance, is a powerful narcotic. It has no such effect on me, however ... after I had knee surgery, the nurses kept giving me more and more when it wasn't working at all, and they might just as well have pumped me full of syrup of ipecac. No pain relief, no happy magic floaty land, just an endless display of my gastro-intestinal system discovering reverse.

(My pain reliever of choice is Toradol (aka Ketorolac) but I don't believe it's a narcotic)
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  #4  
Old 03-17-2002, 04:49 AM
casdave casdave is offline
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I would imagine that LSD is right up there, the effect can be felt from far smaller dosages than any of the opiate family.
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  #5  
Old 03-17-2002, 08:09 AM
choosybeggar choosybeggar is offline
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Quote:
Originally posted by casdave
I would imagine that LSD is right up there, the effect can be felt from far smaller dosages than any of the opiate family.
LSD is potent alright. So potent that you may be hallucinating that it is an opiate.
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  #6  
Old 03-17-2002, 08:26 AM
David Simmons David Simmons is offline
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Quote:
Originally posted by Dragonblink
Keep in mind that narcotics, like all drugs, affect different people differently. I'm sure morphine, for instance, is a powerful narcotic. It has no such effect on me, however ... after I had knee surgery, the nurses kept giving me more and more when it wasn't working at all, and they might just as well have pumped me full of syrup of ipecac. No pain relief, no happy magic floaty land, just an endless display of my gastro-intestinal system discovering reverse.

(My pain reliever of choice is Toradol (aka Ketorolac) but I don't believe it's a narcotic)
Same here. I hope that I don't ever need a good pain-reliever. I'm sure that the doctors will take awhile believe that morphine just doesn't work for me.
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  #7  
Old 03-17-2002, 08:49 AM
kniz kniz is offline
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Yesterday, I was watching a show on poisonous fish and snakes of the ocean. They said that pain killers found in the poisons of these fish were many times stronger than morphine.
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  #8  
Old 03-17-2002, 10:01 AM
handy handy is offline
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What's The Most Powerful Narcotic?

Love.
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  #9  
Old 03-17-2002, 12:52 PM
Niobium Knight Niobium Knight is offline
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Quote:
Originally posted by Dragonblink
Keep in mind that narcotics, like all drugs, affect different people differently. I'm sure morphine, for instance, is a powerful narcotic. It has no such effect on me, however ... after I had knee surgery, the nurses kept giving me more and more when it wasn't working at all, and they might just as well have pumped me full of syrup of ipecac. No pain relief, no happy magic floaty land, just an endless display of my gastro-intestinal system discovering reverse.

(My pain reliever of choice is Toradol (aka Ketorolac) but I don't believe it's a narcotic)

Hmm, NEVER heard of it having no affect before. Sure it might not reduce the pain, but it will have an effect on your mind.
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  #10  
Old 03-17-2002, 01:39 PM
red_dragon60 red_dragon60 is offline
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From the research paper I did, heroin is very high up there. It is more potent than morphine, with a ratio of 2:3 in regards to heroin:morphine doses and effectiveness. The H-bomb works exactly like morphine, and it's hard to tell the difference between the two. However, because of the two acetyl groups tagged onto the morphine molocule of heroin, it crosses the blood-brain barrier much faster and more effectively, making a sense of euphoria almost instantaneous. It kicks in fully about two minutes after administration.


Interesting side note: heroin was first marketed as a replacement to morphine, billed as having no addictive properties.
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  #11  
Old 03-17-2002, 04:49 PM
Dragonblink Dragonblink is offline
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Quote:
Originally posted by Niobium Knight


Hmm, NEVER heard of it having no affect before. Sure it might not reduce the pain, but it will have an effect on your mind.
[mild hijack] It didn't have any effect on my mind. The only thing making me less than my usual self was the fact that I was in a LOT of pain. If it'd sent me on a happy little trip I wouldn't've minded the pain so much. [/mild hijack]
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  #12  
Old 03-17-2002, 05:12 PM
Qadgop the Mercotan Qadgop the Mercotan is offline
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Medically speaking, narcotics mean opiates. The more strongly the opiate molecule binds to the opiate receptor, the more powerful it is. One of the most powerful is Sufenta, binding ten times more strongly than even fentanyl.

http://www.pain.com/onlinepainjourna...ech_opiods.cfm
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  #13  
Old 03-17-2002, 05:42 PM
Zweistein Zweistein is offline
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I would interpret "most powelful" differently.
For me, for obvious reasons, it's nicotine.
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  #14  
Old 03-17-2002, 06:53 PM
Mr. Frink Mr. Frink is offline
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As others have pointed out, the word "narcotic" refers to a specific type of drug. LSD and Nicotine are not narcotics.

However, due to the federal gov'ts overuse of the word, it seems as though the word "narcotic" now represents any drug in the mind of the public. Kind of annoying. But I guess it provides a useful loophole. When I went away to college, my dad told me that he'd cut off my college funding if he found out I used any narcotic. As an occassional user of cannabis, I agreed, hoping that I could get away with my smoking...considering that marijuana is not, strictly speaking, a narcotic...
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  #15  
Old 03-17-2002, 08:12 PM
Qadgop the Mercotan Qadgop the Mercotan is offline
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Unfortunately, frinkboy, that depends on who's doing the defining. By some medical definitions, any drug which reduces pain and induces sleepiness is a narcotic. Marijuana would qualify by that description. By other definitions, only those drugs which activate the opiate receptors qualify. In legalese, it can be any controlled substance, including pharmaceutical testosterone.
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  #16  
Old 03-17-2002, 08:20 PM
Mephisto Mephisto is offline
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Thanks

Thanks for the comments/info people, especially those of you who provided links. I guess I should have used the word "painkiller" instead of "narcotic," but fortunately everybody seemed to understanad what I meant. I guess I chose my wording because it's mostly just narcotics that I've seen prescribed for serious pain.

Thanks for the straight dope, everybody.
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  #17  
Old 03-17-2002, 08:27 PM
Dr_Paprika Dr_Paprika is offline
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Courts define narcotics differently from most doctors to include drugs restricted by law. To avoid confusion, many doctors refer to opiates.

Morphine and codiene both come from poppies and are natural opiates. Semi-synthetic opiates are created by chemical processing, e.g. heroin is diacetylmorphine. More processing tends to mean a more potent drug, meaning a smaller amount has the same effect. The four members of the fentanyl family (Lo, Remi, Al and Su) are completely synthetic and more than 80 times more potent than morphine.

But this does not mean fentanyl, or sufenta, is necessarily the best painkiller. Furthermore, due to its short half life, the withdrawal effects can be very severe. Not all pains even respond to opiates.
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  #18  
Old 03-17-2002, 09:17 PM
The Ryan The Ryan is offline
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Quote:
Originally posted by handy
What's The Most Powerful Narcotic?

Love.
Actually, Love is classified as a hallucigen.
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