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  #1  
Old 11-04-2010, 01:32 PM
naita naita is offline
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30 kg per kg bodyweight! LD50 for sucrose seems whack

In the wikipedia article on LD50, the example for sucrose seems absurd. How can you administer 30 kg of sucrose per kg bodyweight? Drop a bag on the rat?

http://en.wikipedia.org/wiki/LD50#Examples
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  #2  
Old 11-04-2010, 01:36 PM
Giles Giles is offline
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29,700,000,000 ng = 29.7 g, so the lethal dose is about 1/34 of the body mass: you'd have a full stomach with that amount inside you, but I suppose it could be done.

Last edited by Giles; 11-04-2010 at 01:37 PM..
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Old 11-04-2010, 01:46 PM
Colophon Colophon is offline
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I prefer the "drop a bag on the rat" explanation, myself. Say a rat weighs about 400g - a 30lb sack of sugar ought to the job nicely.
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Old 11-04-2010, 02:19 PM
chorpler chorpler is offline
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Quote:
Originally Posted by naita View Post
In the wikipedia article on LD50, the example for sucrose seems absurd. How can you administer 30 kg of sucrose per kg bodyweight? Drop a bag on the rat?

http://en.wikipedia.org/wiki/LD50#Examples
I think your math is off by a factor of 1000 -- as Giles points out, 29,700,000,000 ng/kg is about 30 grams per kilogram.

My question is, what would actually happen if you consumed a lethally huge dose of sugar? We know how lethal doses of things like water and salt kill you ... what does sugar do at a lethal dose?

Last edited by chorpler; 11-04-2010 at 02:20 PM..
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Old 11-04-2010, 02:21 PM
chorpler chorpler is offline
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Quote:
Originally Posted by naita View Post
In the wikipedia article on LD50, the example for sucrose seems absurd. How can you administer 30 kg of sucrose per kg bodyweight? Drop a bag on the rat?

http://en.wikipedia.org/wiki/LD50#Examples
I think your math is off by a factor of 1000 -- as Giles points out, 29,700,000,000 ng is about 30 [i]grams[/b] per kilogram.

My question is, what would actually happen if you consumed a lethally huge dose of sugar? We know how lethal doses of things like water and salt kill you ... what does sugar do at a lethal dose?

ETA: OK, my second question is, have they actually determined the LD50 of sucrose experimentally, or is this just a guess?
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Old 11-04-2010, 02:56 PM
awldune awldune is offline
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So if you weigh 150lbs you would have to eat 4.5lbs of pure sugar to have a 50% chance of dying.

http://en.wikipedia.org/wiki/Hyperglycemia

Quote:
Acute hyperglycemia involving glucose levels that are extremely high is a medical emergency and can rapidly produce serious complications (such as fluid loss through osmotic diuresis).
I think the basic idea is that your kidneys go crazy and you become very dehydrated. I doubt it is entirely healthy for the kidneys, either.
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Old 11-04-2010, 03:40 PM
naita naita is offline
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Of course I'm wrong by a factor of 1000. That'll teach me to taunt the people who think having kilograms as the base unit is bad. My brain was so stuck in the "nano" means a factor of 10^9 mode it took me a while to accept your replies were right.
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Old 11-04-2010, 03:43 PM
naita naita is offline
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Quote:
Originally Posted by chorpler View Post
ETA: OK, my second question is, have they actually determined the LD50 of sucrose experimentally, or is this just a guess?
The table mentions animal (rat) and administration route (oral), so it's probably determined experimentally.

Now I have to worry about accidentally eating two kilogram bags of sugar.
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  #9  
Old 11-04-2010, 03:50 PM
purplehorseshoe purplehorseshoe is offline
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*crunch* *munch* *chew*


*gulp*


Oops.
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  #10  
Old 11-04-2010, 04:47 PM
lazybratsche lazybratsche is offline
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Quote:
Originally Posted by awldune View Post
So if you weigh 150lbs you would have to eat 4.5lbs of pure sugar to have a 50% chance of dying.

http://en.wikipedia.org/wiki/Hyperglycemia



I think the basic idea is that your kidneys go crazy and you become very dehydrated. I doubt it is entirely healthy for the kidneys, either.
4.5 lbs of sugar would probably just kill you by sucking all of the water out of the rest of your body by osmosis.
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  #11  
Old 11-05-2010, 01:28 AM
TriPolar TriPolar is online now
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You won't die if you drink several gallons of diet soda at the same time to balance things out.
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  #12  
Old 11-05-2010, 05:49 AM
Random Design Random Design is offline
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Quote:
Originally Posted by chorpler View Post
I think your math is off by a factor of 1000 -- as Giles points out, 29,700,000,000 ng is about 30 [i]grams[/b] per kilogram.

My question is, what would actually happen if you consumed a lethally huge dose of sugar? We know how lethal doses of things like water and salt kill you ... what does sugar do at a lethal dose?

ETA: OK, my second question is, have they actually determined the LD50 of sucrose experimentally, or is this just a guess?
Isn't the term "lethal dose" self-explanatory?
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  #13  
Old 11-05-2010, 11:03 AM
aruvqan aruvqan is online now
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Originally Posted by Random Design View Post
Isn't the term "lethal dose" self-explanatory?
i still have the mental image of dropping a whole bag of sugar on the poor little rattie ...
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