Old 03-09-2018, 08:02 PM
Hari Seldon is offline
Join Date: Mar 2002
Location: Trantor
Posts: 12,761

On phages

Today's column discussed bacteriophages, generally called phages, for the purpose of fighting bacteria. One problem with them is that bacteria can evolve to avoid them and rather quickly. More than 60 years ago, I helped with the following experiment involving the so-called T-phages which infect E. coli. We took a liter flask and filled it with growth medium. After inoculating with a single strain of the coli (it was a single strain because we grew it on a petri dish and took a piece of a single colony that had grown there), we let it grow for a day and the flask clouded up. We then added some phage to the flask and the next day the flask had cleared and the dead bacteria formed a mat at the bottom. But then some of the bacteria mutated to be resistant and the flask clouded by the next day. But some of the phage must have mutated and the flask cleared again. We did not continue the experiment because the nutrient would run out and the waste products would accumulate so we ended it.
Old 03-10-2018, 07:53 AM
Kimera757 is offline
Join Date: Aug 2015
Posts: 490
Here's the link: https://www.straightdope.com/columns...iotics-crisis/

Links are posted so rarely I wonder if people have trouble linking them. Mobile phone issues?
Old 03-10-2018, 12:43 PM
Hari Seldon is offline
Join Date: Mar 2002
Location: Trantor
Posts: 12,761
Ah, pure laziness on my part. Apologies.
Old 03-20-2018, 12:36 PM
N9IWP is offline
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Join Date: Aug 2001
Location: Southeast MN
Posts: 6,232
One instance where phages were used:

But, if phages can kill bacteria and make survivors evolve to be vulnerable to drugs, then a one-two punch of phage and drugs could knock out any infection, resistant or not


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