The most probable state of the art solution is to send seven or eight missions, the first few unmanned, and use them to establish remote replenishment stations in orbit around mars, and finally around earth.
You get to test run the system each time to be sure that you are going to be able to thread the needle at each step of the final trip. First, you establish the Mars Mission return cash of non perishables, fuel, electronic replacements, reaction mass. You practice docking with it without ground control assistance several times, in lunar orbit.
Then you send out the Mars Lander, unmanned, and orbit it around Mars. It has docking ability and several modules available for its landing, and Mars take off missions. You probably also send a second unmanned Lander to establish that your landing site is useful, and load that up with resupply stuff, for the layover period of the mission.
Now you launch your Mars outbound resupply module, with enough rockets, and fuel to make the Hohmann Transfer orbital change burn for your final vehicle. With everything in place, you send the perishable supplies for outbound, land, return segments to their appropriate location, and verify that everything is in place. Then, your actual trip begins, first to the outbound resupply module, then to the Mars Lander module, then to the surface, then assemble your shelter. Then you have layover. During this time, you will have some ability to do real science. Then it’s time to start packing up, and transmitting your data. (Mars Rocks are going to be grains of sand, and smaller, with the cost of energy.)
Now comes Mars liftoff, dock with the return resupply module, and head back to Earth, while launching the Earth Landing module, back home. Dock with the landing module; jettison the cargo with ablative survival type low fuel Landers. Transfer to the Shuttle, or current equivalent. Come home to a tickertape parade.
The overwhelming barrier to this sort of solution is that it requires a continuous dedication to eight very expensive space missions, covering three or more election cycles, and almost no increase in benefit to what one would expect of eight non manned missions to three or four other targets.
I ain’t seein’ it happen.
Tris