I’ll put forth F. Murray Abraham, who played Salieri in 1984’s Amadeus (a role for which he won the Oscar for Best Actor). Amadeus was Abraham’s first work of any note; before that, his biggest role was probably “Pile Of Leaves” on Fruit Of The Loom commercials. His IMDb resume pre-1983 is a rather short list of one-shot roles on various TV shows.
Anyway, Amadeus came out in 1984, and Abraham was born in 1939, making him 45 at his first big gig.
David “Dudu” Fisher. His first acting job was Jean Valjean in the Israeli production of “Les Miserables.” He then took the role on Broadway at the age of 42.
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Michael Clarke Duncan qualifies, more or less.
IMDB credits him with a bunch of small roles as a bouncer or security guy going back to the mid-90’s, but nothing of note prior to The Green Mile in 1999. Apparently his early roles wouldn’t have been much of a stretch… prior to getting into acting, he worked as a bodyguard.
He may not qualify simply because he hasn’t done much of note since then (though I see his body of work this year includes a role in Kung Fu Panda, which clearly will do well during next year’s award season)
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Daredevil and Sin City don’t count as “much of note”?