Are there any creatures that are wholly inedible for humans to eat?

Regarding echinoderms, some are certainly edible. Sea urchin gonads are popular as sushi, and sea cucumbers are also extensively harvested for food for the Asian market.

It’s true that a number of invertebrates don’t have much in the way of “flesh” to eat, but they could probably be made into soup. The tissue isn’t poisonous, which I think is what the OP is most interested in.