# Are there dopamine reuptake inhibitors with a stronger affinity than amphetamines

**URL:** <https://boards.straightdope.com/t/are-there-dopamine-reuptake-inhibitors-with-a-stronger-affinity-than-amphetamines/766724>\
**Category:** Factual Questions\
**Created:** [September 24, 2016, 1:59pm UTC](https://boards.straightdope.com/t/are-there-dopamine-reuptake-inhibitors-with-a-stronger-affinity-than-amphetamines/766724 "2016-09-24T13:59:11Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![Wesley\_Clark](https://sea3.discourse-cdn.com/straightdope/user_avatar/boards.straightdope.com/wesley_clark/32/20581_2.png) [@Wesley\_Clark](https://boards.straightdope.com/u/Wesley_Clark)\
**Post date:** [September 24, 2016, 1:59pm UTC](https://boards.straightdope.com/t/are-there-dopamine-reuptake-inhibitors-with-a-stronger-affinity-than-amphetamines/766724/1 "2016-09-24T13:59:11Z")

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My understanding is amphetamines (legal and illegal) work via dopamine reuptake inhibitors.

In theory, shouldn’t a reputake inhibitor with a stronger affinity than something like meth be a drug that can end a bad meth trip? Wouldn’t that displace the meth (which is dumping loads of dopamine into the system) with something that dumps a far smaller amount of dopamine? or is my biology wrong?

So my question is, is there and is it used for meth overdose? I know that naltrexone is used for opioid overdose since it blocks the opioid receptors. I know that drugs like antipsychotics are used for meth users who end up in hospitals. But are there dopamine reuptake inhibitors with a stronger affinity that can displace the meth, and basically make it useless?