relevant (meta)study finds that stopping WMM (Weight Mmt Meds like Ozempic)works, just don’t ever stop using it ‘cause you regain weight 4 times faster than with BWMP (behavioural changes).
Results Of the 9288 titles screened, 37 studies … were included. Average treatment duration was 39 (range 11-176) weeks, with average follow-up of 32 (4-104) weeks. The average monthly rate of weight regain was 0.4 kg … All cardiometabolic markers were projected to return to baseline within 1.4 years after the cessation of WMM. Weight regain was faster after WMM than after BWMP (by 0.3 kg … monthly), independent of initial weight loss. Estimates and precision were robust in sensitivity analyses.
Conclusions This review found that cessation of WMM is followed by rapid weight regain and reversal of beneficial effects on cardiometabolic markers. Regain after WMM was faster than after BWMP. These findings suggest caution in short term use of these drugs without a more comprehensive approach to weight management.
Oh wow! I’m really glad i didn’t try them. I was surprised when my nutritionist said, “i don’t think you are a good candidate for ozempic”, because it hadn’t occurred to me to take it. But she said most of her patients saw her because they were looking for a prescription.
I hear rumblings about insurance dropping coverage. Had that been a problem for people in this thread?
It is a treatment not a cure. The model is thinking of obesity as a chronic and typically incurable disease. Insulin forever is expected once one has IDDM and these meds are forever as well. Maybe a minimal maintenance dose can be found, but going off? Not likely.
I also hope those on these meds are also doing the non pharmacological treatment components of a decent nutrition and exercise plan … I suspect most but not all are.
Not a small number of people are able to put Type 2 diabetes into varying levels of remission by losing weight and exercising, but that’s all it really is.
Example: I used to work with a woman whose dad “cured” himself of diabetes by losing a lot of weight, which he actually did because the orthopedic surgeon wouldn’t replace his knees until he did that. After he had the knee replacements, he went from diet-controlled diabetes, to back on insulin for several months, due to the extra stress on his body. He wasn’t very happy about that, but at least it was temporary. I found out recently that he died a few years ago, from an unrelated cause.
I have been exercising 4-6 times per week (40-60 minutes each time) since I started taking Ozempic-like Rx. I also try to keep moving more throughout the day. I’m not sure I’ve improved my nutrition plan, but my diet is not terrible. I’ve lost 30 pounds and my A1c is back to “normal.” I plan to keep exercising. I’m enjoying getting heathier.
$44 for lunch will not make Cheapskates Corner but food and company was good.
Giant very tasty cinnamon bun with a small latte plus a ham and cheese toastie + iced coffee for Bruce was never going to be value for money.
It’s too bad the place is so expensive as it’s very convenient. Had no other way to pick up the Dyson and lunch with Bruce is always a treat.
The meal carried me to a very light supper after post prandial nap. The place is too expensive for bread but talked them in 1/2 sourdough loaf for $5.50 which again will be very good but $$$.
Don’t see a couple getting out for less that $40-50 a go
Should have tried The Nest almost next door but can’t find prices. Their plum tart looks delicious.
Actually prices do show would have been little savings and less choice of items.. The pastry on that Frangipani looks top notch.
That’s what I get for being poor pensioner living in high end suburb. Hungry Jacks my go to and P J Obriens for the $10 full meals on weekdays.
Broke into 105 kg range :sparkler :despite indulgent eating in the New Year so new Ozempic routine is working with fewer side effects. Bit more food noise for sure but the port cullis moves down more leisurely and I’m enjoying the meals.
For what it’s worth: as many here know, I’m a frequent flyer re colonoscopies due to my hobby of developing precancerous polyps.
The first scope I had after starting Ozempic - about 6 months afterward - yielded the same “see you in a year” as the previous one.
The second one, 18 months after starting Ozempic, and after roughly 100 pounds of weight lost, found NONE.
The weight loss is likely the main factor, but there are some studies suggesting that GLP1s can possibly be beneficial in reducing risk of colorectal cancer regardless of diabetes / weight.
which really makes sense, as - from a more historic POV (think: 1000 generations) - constant high influx into the GI system is definitely an aberration/no normal in humans and their GI system.
IOW: eating in excess like we do for 2-3 generations (facilitated by the industry) - is just like running you GI tract at max. stress/revolutions for 24/7 (compared to 997-998 generations before where you always had periods of litte/normal/excess intake, alternating… (highly skewed to “little”) and excess might have been 3 days in a year when you slaughtered an animal and had to keep things from spoiling).
So, interesting to see if the whole GLP-1 impact shows up sooner or later in epidemological/broad scale GI-cancer (or other) cases.
My guess is it will show up as “better numbers”, b/c of the long tail of losing weight (becoming more active, higher activation rate, etc…)
It seems that the drugs - for IP reasons - are moving from “highly proprietry” into “generic” territory, and might become "ibuprofen” or ASS in the near future. IIRC, IP for novo-nordisks formula runs out in Brazil in 2026.
Related: one reason for pricecuts of Doritos and Cheetos: GLP-1 users don’t overeat on salty/greasy potatoes anymore - and demand is coming down.
This is kind of me, too. My doctor and cardiologist wanted me to lose weight, but my doctor was reluctant to prescribe any WMM. I lost 70 lbs on dietary changes and exercise. Haven’t gained any back in a year (although I’d like to lose a little more). I’m also glad I wasn’t suggested the other route.
more future-relevant information - again, that stuff might become very common/inexpensive:
… the imminent expiry of a patent protecting semaglutide, a protein that mimics a hormone telling your brain that you’re not hungry. It’s a key ingredient in Novo Nordisk’s wildly popular injectable weight-loss drug Ozempic.
Novo Nordisk’s India patent will expire in March. And the country’s colossal pharma production industry is gearing up to take advantage by selling generic versions.
Analysts there predict a price war that could drive the cost of some weight-loss drugs down by as much as 90 percent in India – and possibly in other countries too.
Only distantly related - I’ve lost 70 lb on Ozempic mostly in the first year. Switched to Lira glutide due to supply constraints which worked okay for a year then stopped working ( known thing ).
Back on Ozempic at .5 mg and working but stalled out at 230 lb. Would like to keep moving lower ( I’m 78 good diet…no exercise …don’t bother )
Learned something new. Food coma https://my.clevelandclinic.org/health/d … /food-coma
I would wake up in the morning feeling lots of energy. If I had mostly protein for brekkie ( Australian for breakfast ) then no problem …energy persists. But add in some carbs and all I want to do is go back to sleep and often I do.
At least I know why now but they don’'t know the exact reason. Some blood sugar spike.
I’ve been eating roll mop herring with small slice of sourdough bread and cream cheese for morning meal which is sufficient given Ozempic.
No sleepy effect. Easy source of morning protein.
Apparently the vinegar in the roll mop blunts the sugar spike by about 20% in clinical tests. For me seems to knock out the sleepiness.
If I have peanut butter and jam tho instead of the roll mop …still get sleepy.
The roll mop comes in a big jar with vinegar …it’s almost empty of fish now but loads of vinegar left. Looks like I’ll add a teaspoon of vinegar to the morning meal.
