Gone Baby Gone. Just sad.
2nd vote for Memento
Sixth Sense hit me hard, didn’t see it coming
The Conversation. I dare not say more.
Beautiful scene – and music. Check it out on YouTube.
From The Bridge over the River Kwai: “Madness!”
The Attic (Carrie Snodgress, 1980)
Sorry, can’t find a link to the final scene anywhere.
Sixth sense.
Even after numerous viewings, the ending of Local Hero still evokes melancholy in me.
Final scene in Blazing Saddles.
Also known as “the way every Western ended, they just weren’t honest enough to show it.” 
It’s not quite the last scene of the movie, but it’s close: I love the rooftop scene in “Blade Runner” with Rutger Hauer’s final speech. I think that it’s perfect. What’s unbelievable is that parts of that were improvised.
“Being There” also has a great final scene.
Definitely a great scene – I totally agree.
The final scene in the musical version of Les Miserables is pure genius.
Also, Au Hasard Balthazar.
The Shining.
Even if it’s not exactly clear what the photograph is supposed to mean.
And speaking of Kubrick.
2001: A Space Odyssey
“The unknown future rolls toward us. I face it, for the first time, with a sense of hope. Because if a machine, a Terminator, can learn the value of human life…maybe we can, too.”
Oh, good one re The Shining. After having seen it so many times I’m now pretty sure what it’s supposed to convey but the first time I saw it, whoo boy did that stay with me for a long time. Along those same lines, the last shot in Polanski’s Repulsion is a long closeup of a photo showing the main character (Catherine Deneuve) as a child with a look on her face that is just . . . disturbing.
The takeaway I had from that closing shot was that Jack was now a permanent resident (ahem… ghost) of the Overlook. It fits with the book as well since he was obsessed with the history of the hotel.
Maybe not “Best”, but worth an honorable mention.
The Grey
You did see the actual ending, right?
The one AFTER the credits? :rolleyes:
Let the sunshine in.
How about the text at the end of American Graffiti?
It alludes to the future of the four lads.
One was killed by a drunk driver in December 1964. Another was missing in action.
ISTR some eerie atmospheric sound (music?) during this finale.
This was the first firm with a “what happened to them over the years” blurb, was it not?
Of course, there was a sequel, More American Graffiti.
ETA: Turns out Terry “The Toad” actually faked his own death.