Best cold medicine

Girl…you tryna kill me? :skull_and_crossbones: :scream:

No, I do love your mindset. :wink:

Do what you can, that’s safe for you, to make YOU feel better.

I like to sip good scotch when i have a cold.

Chicken soup from a restaurant.

Time and Rest. I used to swear by Nyquil, but now it will allow me to sleep, but I’m up at 2am and unable to get back to sleep and don’t wanna double-dip the stuff.

I’ve accepted that it’s gonna take a week or so, and not much I do is gonna change it. Rest as much as you can, keep tissues handy and suffer through it.

Good choices. Using a combo generally wastes money and gives you a drug you dont want or need.

Not the best idea. Just take the individual drugs.

Yes, one great reason to not use “all purpose” drug mixtures.

Good choices, and i never take that stuff in the same nostril two nights in a row, and in fact try to limit myself to once a week.

Not terrible, but BC powder has caffeine, which you dont want. And only one shot. Otherwise you sleep poorly during the night.

Not “topical” - maybe you meant OTC?

DO NOT CHEW pseudoephedrine. Very dangerous.

For patients taking pseudoephedrine extended-release capsules:

"** Swallow the capsule whole. However, if the capsule is too large to swallow, you may mix the contents of the capsule with jam or jelly and swallow without chewing.*
** Do not crush or chew before swallowing.*

For patients taking pseudoephedrine extended-release tablets:

** Swallow the tablet whole.*
** Do not break, crush, or chew before swallowing.*"

Link doesn’t say it’s dangerous; extended release pills are coated to dissolve slowly so you get a lower dose over a longer period of time instead of all right away, and it lasts longer. Breaking the coating by chewing defeats that purpose.

It says not to do it.
Rosemont | Information For Patients On The Dangers Of Tablet Crushing.

2. You could be risking an overdose

Crushing or splitting enteric-coated or modified-release medication risks too much of the drug being released into your bloodstream too soon.[2]

Not only does this increase the risk of overdose and experiencing side effects, it also means there could be a period of time you won’t be benefiting from it at all.[[2]]

Cite after cite says no.

Take the capsules or tablets with a full glass of water. Swallow whole. Do not crush or chew the capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects.

Yes, I chew one to promote the faster acting though I don’t think mine are extended release. I wouldn’t say I’ve noticed any extra side effects but I can feel it working in about 20 minutes.

cracks knuckles, waits for insults

So here are some things that might work that haven’t been mentioned.

800mg a day of cimetidine split into 400mg in the morning, 400mg in the evening. This medicine is available OTC to treat acid reflux. However it is an inhibitor of the H2 histamine receptor, which is found on suppressor T cells in the immune system. What that means is when you take cimetidine, it blocks the immune cells that keep your immune system in check, making your immune system stronger. Its been researched as a tool for helping with cancer and infections due to its ability to increase the activity of the immune system.

Cimetidine, a selective histamine-2 receptor antagonist, has attracted interest because of its potential as an immune response-modifying drug. Most data suggest that cimetidine has a stimulatory action on the immune system, possibly by blocking of receptors on subsets of T-lymphocytes and inhibiting histamine-induced immune suppression. Several studies have shown that cimetidine can affect the relative number of CD8 + ve lymphocytes and increase the NK cell activity as well as the antibody-dependent cellular cytotoxicity. Cimetidine has also been used successfully to restore immune functions in patients with malignant disorders, hypogammaglobulinemia and AIDS-related complexes

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In the past, when I was able to use cimetidine at the first sign of a cold, the cold would be gone in about 4 days or so. Now that I can’t use it anymore because it interacts with some Rx meds I’m on, my colds last for 3 weeks now.

Massive warning. Cimetidine blocks major enzyme pathways involved in metabolizing drugs. So taking it is risky, which is why I had to stop using it when I got sick. Also I don’t know what dangers there are to making your immune system stronger. I don’t know if that increases the risk of developing auto immune disorders. For me, when I used cimetidine, I just used it at the start of a cold and stopped a few days after symptoms were gone.

Another thing that may help is a supplement called andrographis. I don’t know exactly how it works, but it supposedly has broad spectrum anti-viral properties. Many herbal cold remedies have this in it.

https://www.nature.com/articles/s41598-023-46249-y

Andrographis paniculata (Burm. F.) Nees is a medicinal plant previously reported with broad-spectrum antivirals but the mode of inhibition remains elusive.

Another thing you can try is buying the amino acid L-glutamine. Supposedly your immune cells use that for energy, so 5-10g a day of that when you have a cold can make your immune system stronger.

To prevent a common cold other than doing things like washing hands and wearing a mask, other things you can try are CPC mouthwash or nasal sprays.

CPC mouthwash (like crest pro health) have antiviral activity that can hopefully reduce the risk of catching a respiratory infection through the mouth. I gargle with this before I go out to events.

https://www.nature.com/articles/s41598-022-18367-6#Sec6

Nasal sprays containing either xylitol or Iota Carrageenan can help make it harder for respiratory viruses to attach to receptors in your nasal passages.

Also if you take zinc lozenges for the cold, it is best to look for zinc acetate, other forms of zinc supplements don’t dissolve nearly as well in saliva. Zinc acetate lozenges are far superior to cold-eeze supplements.

Huh, do you know if the (now more widely available) famotidine has the same effect?

No, it doesn’t. Famotidine is more selective in the H2 receptors it blocks. Cimetidine blocks a far wider range of H2 receptors, including the H2 receptors on immune cells. Famotidine is more selective for the H2 receptors in the gut and doesn’t affect the H2 receptors on immune cells as much.

Thanks. I may stock some cimetidine.