Also, shortly before this fabulous scene, her shock, horror and loss (and stumbling, hair-pulling, face-wrenching fury!) at news of Valmont’s demise. Supreme. LOVE that movie for all time.
More Glenn Close: the retribution she dealt to Jeff Bridges at the end of Jagged Edge . He so had it coming.
–Beck
I would say Sejanus’s arrest in I, Claudius. I love how his smug look (as he thinks he’s getting a promotion) turns to horror as the Senate reads Tiberius’s letter.
“It’s twoo, it’s twoo!”
Although it’s a bit of a stretch to call it “comeuppance” … 
Pretty much all of V for Vendetta, but especially this:
[V is surrounded by Creedy’s gun-toting fingermen after V and Creedy have just killed the Chancellor]
Creedy: Defiant until the end, huh? You won’t cry like him, will you? You’re not afraid of death. You’re like me.
V: The only thing that you and I have in common, Mr. Creedy, is that we’re both about to die.
Creedy: How do you imagine that’s gonna happen?
V: With my hands around your neck.
Creedy: Bollocks. Whatchya gonna do, huh? We’ve swept this place. You’ve got nothing. Nothing but your bloody knives and your fancy karate gimmicks. We have guns.
V: No, what you’ve have are bullets, and the hope that when your guns are empty I will no longer be standing, because if I am you will all be dead before you’ve reloaded.
Creedy: That’s impossible. Kill him.
[the fingermen open fire on V, but he still stands after their clips are empty]
V: My turn.
Also, John Turturro (Bernie) and Gabriel Byrne’s (Tom) final scene together in Miller’s Crossing:
Bernie: (begging Tom to spare him again, despite all the hell he’s caused) Look in your heart, Tom! Look in your heart!
Tom: What heart? >bang<
Am I really the first to mention The Usual Suspects?
From the moment that…
Agent Kujan sees “Kobayashi” on the bottom of the coffee mug until the final “he’s gone” from Kevin Spacey’s character
…is the most brutal comeuppance I can think of that didn’t involve violence. The whole montage of images and quotes was just mind-blowing the first fifteen times I watched it.
Just thought of another one: Clint Eastwood’s revenge on Miles Mellow in The Eiger Sanction.
“Jonathan, you’re not going to leave me here!!”
Oooh, that was a good one (and how appropriate Agrippina should mention it). Also, while a bit sick and wrong and nasty, Livia’s look of horror when Caligula fondles her on her deathbed and assures her she’ll be in hell “forever and ever and ever…” rather than a goddess with impunity. While he was evil incarnate, she deserved that.
I mentioned The Godfather earlier but didn’t mention the first “This is why we don’t beat Sonny Corleone’s sister” scene. That was one of filmdoms truly great and inspired and impressive asskickings that was. (Gianni Russo, who played Carlo, said the look of terror on his face is not acting because James Caan got really really into the part really did beat the hell out of him, only later realizing how much actual damage he’d done.)
Mason “Fire Marshall Bill” Verger’s porcine end in Hannibal is also up there even if his character was so cartoonish that you expected to see him somehow don a black hat and moustache and from his wheelchair tie Clarice to the railroad tracks.
Scar’s literal fall from power at the end of The Lion Den is good both in the cartoon and onstage. Of course most Disney villains have great comeuppances.
Fagin’s loss of his treasure was the perfect punishment for him in the film musical Oliver. It left him still free for the good that’s in him but broke to punish the “bad 'un” in him in. (In the book of course he was hanged but then in the book he was a far dirtier villain.)
Speaking of antisemitically drawn characters in English literature, Shylock’s comeuppance is great at the end of Merchant, especially as kosherly hammed by Pacino in the most recent adaptation as he’s spent the last several minutes salivating while sharpening his blade and doing his “Oh, tis a second Daniel! HOO-WAH! Say hello to my leetle Jewish blade…” evil stuff.
I should specify that by comeuppance for Shylock I’m not referring to his forced conversion and death but to his turmoil at having to take a pound of flesh without drawing blood. (Is there a way to do that, I wonder, in today’s technology…)
I should specify that by comeuppance for Shylock I’m not referring to his forced conversion and death but to his turmoil at having to take a pound of flesh without drawing blood. (Is there a way to do that, I wonder, in today’s technology…)
And speaking of Shakespeare, the demolition at the end of Porky’s 1 was good.
Firefly and Serenity mentioned here too many times? …Never!
[SPOILER]The Operative has learned (through Mr. Universe himself) that Mal and his crew are preparing to visit Mr. Universe’s planet, and gathers all the firepower and battleships in that quadrant of the galaxy.
They wait just above orbit, hovering above the ion clouds–and soon enough, Serenity appears, high-tailing it frantically, headed straight towards them.
“Bastard’s not even changing course,” the Operative smirks…
…and BOOM! Out through the clouds appear a whole horde of Reaver ships, fast on Serenity’s track. And the Operative’s ‘oh, shit’ look is priceless.[/SPOILER]
Best come-uppance ever.
I was going to mention Dean Wormer and the parage scene too. 
Comeuppance for me is always Robby Benson in One on One. He has just won the basketball game, proven himself as a player, and now the coach wants to patch things up. Instead, Henry Steele (Benson) delivers the line “Up your a$$ with a red-hot poker” - this before he presumably departs to a better basketball program.
Yeah, that was awesome :D. Also:
You gotta love the part where the Operative’s trademark finishing move doesn’t work on Mal because of his war injury. It’s cool that Mal then got to reciprocate the ass-whuppin’, but the best part is how he proceeds to bring the Operative’s idealism crashing down by showing him “a world without sin.”
I’m also rather a fan of Longshanks’ comeuppance in Braveheart. Wallace was executed and Scotland was ultimately subjugated by England, but the prince wasn’t interested in giving him some grandchildren AND the princess had gone and cuckolded him with the child of his enemy.
“I’ve spent the last few years building up an immunity to iocane powder.”
But the Sicilian never knew it. He croaked thinkng he had won.
Better Prince Huperdink. “I knew it!” or has already been mentioned, Count Rugen.
A Bronx Tale “Okay, now you can’t leave…”
Spiderman “I missed the part where that’s my problem”
Did you miss the point of Spider-Man? Peter’s refusal to stop the robber from making off with the wrestling match take–which is what directly leads to his being able to say that line–is what causes his uncle/foster father’s death at the hands of the robber a few moments later. It’s safe to say that Peter regretted uttering that sentence more than any other sentence in his entire life.
Sure, but without foreknowledge of events I would have gladly said it.
I love the scene in Butch Cassidy and the Sundance Kid, where one of Butch’s gang (Harvey Logan, played by Ted Cassidy) decides he’s taking over the gang and challenge’s Butch to a fight. Here’s the dialogue:
Butch Cassidy: No, no, not yet. Not until me and Harvey get the rules straightened out.
Harvey Logan: Rules? In a knife fight? No rules.
[Butch immediately kicks Harvey in the groin]
Butch Cassidy: Well, if there aint’ going to be any rules, let’s get the fight started. Someone count 1,2,3 go.
Sundance Kid: [quickly] 1,2,3, go.
[Butch knocks Harvey out]
I loved this movie throughout and liked the ending as well.
I didn’t remember that as resolved or anyone getting a comeuppance if the whole movie was one reality that didn’t actually take place? 
Again, I’m not sure on this one; did the agent deserve to be duped and this is a true comeuppance?
Not sure that actually qualifies as a comeuppance – Lucifer actually comes back to continue to bedevil Kevin Lomax.
One of my favorite comeuppance scenes is at the end of Lipstick, after the man who has already raped Chris McCormick (Margeaux Hemingway) and gotten away with it, then rapes her little sister. Big sis goes pretty much postal, using a high-powered hunting rifle to kill the guy. The best moment is after the rapist’s van has turned over while he’s trying to escape; as he crawls out, Chris drills him right in the crotch, then finishes him off with a chest shot.