# Can the liver benefit from a "rest"?

**URL:** <https://boards.straightdope.com/t/can-the-liver-benefit-from-a-rest/699583>\
**Category:** Factual Questions\
**Created:** [September 26, 2014, 1:32am UTC](https://boards.straightdope.com/t/can-the-liver-benefit-from-a-rest/699583 "2014-09-26T01:32:31Z")\
**Posts on this page:** 1\
**Page:** 6

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**Author:** ![DSeid](https://sea3.discourse-cdn.com/straightdope/user_avatar/boards.straightdope.com/dseid/32/20194_2.png) [@DSeid](https://boards.straightdope.com/u/DSeid)\
**Post date:** [September 29, 2014, 6:50pm UTC](https://boards.straightdope.com/t/can-the-liver-benefit-from-a-rest/699583/101 "2014-09-29T18:50:43Z")

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Not sure what that has to do with the request that was made of you **Surreal**. Severe water deficiency can cause renal shut down in no way implies that extra water is protective against kidney damage.

Your cited study in rats notwithstanding in primates supplemental choline was found to be not only [not protective but to cause toxicity](http://www.ncbi.nlm.nih.gov/pubmed/4018729).

> [@](#):
>
> Choline fails to prevent liver fibrosis in ethanol-fed baboons but causes toxicity … choline supplementation exerts moderate hepatotoxicity.

As it turns out, [rodents are not very good models for human alcoholic liver disease](http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496818/).

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