While Kristen Whigg might not be Eddie Murphy in the 80s level of successful, she’s very successful. Lead Roles in: Bridesmaids, Adventureland, Macgruber, Girl Most Likely, The secret life of walter mitty, Welcome to me, Masterminds, Barb and Star Go to Vista Del Mar, Ensemble: Ghostbusters, Supporting roles: Whip It, Despicable Me franchise, Wonder Woman 1984.
Not to mention the various walk ons, Zoolander 2, Anchorman 2, or TV shows: Last Man on Earth, Arrested Development (Lucille when younger).
She seems to have her own quirky indy style on her own projects which might niche her, but they keep giving her money to make them, so they can’t have been that unsuccessful. (I’ve spotted a few I’d missed I’ve added to my list though, being unaware of them before).
And as for Dan Aykroyd, both the Blues Brothers AND Ghostbusters pretty much made him a superstar, never mind being in Dragnet, Trading Places, also never minding: 1941, Driving Miss Daisy, Coneheads, Indiana Jones and the temple of doom, Spies like Us, My Stepmother is an alien, Neighbours, Sneakers, The great outdoors, Grosse Point Blank, some a lot better than others, and a bunch of others BEFORE 2000.