This seems to be the main point of contention here.
We agree that there are far too many possible games to consider all of them using current computers. Any practical solution must then involve ignoring almost all of them.
So what I suggested is a statistical approach. The trick is in how we sample games. We would like wide coverage in the game space, but on the other hand we want to focus our attention on more likely games–ones where not too many mistakes are made. Of course we can’t know what a mistake is in advance, so instead of eliminating suboptimal moves completely, we weight the possibilities so that we try that move less frequently.
We know for instance that a good “opening” is to play as White (yes, I know I’m abusing the word). Do you not think that we could also discover this via the algorithm I suggested? That among millions of games, with noise injected so that we never have the same game twice, we wouldn’t find that White has the advantage?
Or, for instance, that if instead of a queen, we gave black another rook, that this wouldn’t widen the lead even further? We intuitively know this is true because queens are inherently stronger than rooks, but it’s just a heuristic–in an absolute sense, we still don’t know that Black doesn’t have a forced win. We just have a pretty good intuition that if equal skill players were to play a bunch of games with this change, Black would lose more often than before.
So I suggest that the same is true of openings; that we can come up with a table of openings up to some (small!) number of moves, and for each one come up with a win percentage. There’s no reason to believe they’d all be the same–in fact we know they can’t be due to the fool’s mates.
Now, is this number useful? That I can’t say. It sure seems like at the least, you’d be able to find some duds which aren’t currently known. And maybe you’d find some really nice ones which aren’t currently known. These seem like they’d be especially valuable, since even if they aren’t the very peak of the computer’s metric, they’d likely be unknown to the human opponent and therefore confer an advantage.