The worst captain that ship ever had.
They both are definately not OHWs. Bth have been it dozens of movies with majors roles.
Virginia Madsen: Right of the top of my head: Creator, North, Hot Spot, Class {first film}, Dune, Hot To Trot, That horror movie with the evil ghetto ghost and bees and upthread someone mentioned Slam Dance.
Rosanna Arquette: one ofthe girls I had a movie crush on: I first noticed her in Desperately seeking Susan, around the same time she did the Aviator with Christopher Reeves, than Silverado and 8 million ways to die, Amazon woman on the moon, Pulp Fiction (Heroine chick), Whole Nine Yards, Crash, a movie with Eric Roberts where she was a waitress, but wanted to be an actress but she was stuck in a small town. Those are the ones I remember. I am sure there has to be more.
Jim
Although I’ve seen her occasionally in minor roles here and there, has Anna Paquin had a major role since winning her Oscar at age 11?
Does Rogue in the 3 Xmen movies count? 
She was good in Walk on the moon and she was in Finding Forrester but even though it was the biggest female role it was a small role. There has to be others.
Jim
**Linda Blair ** deserves mentioning.
She’s also in The Squid and the Whale.
To crosslink with another thread. If you didn’t blink, he was in one of the last Arrested Development episodes - as the host the TV show “Bud’s Cort” after the show “Judge Reinhold”…
IIRC, she doesn’t need to act. Apparantly she took her money from Graffiti and bought a limo service in LA. From what I hear, she and her partner are multi-millionaires from this little investment.
Carrie Henn. Played Newt in Aliens. Only role.
Ione Skye was also in a fairly recent movie Must Love Dogs. Minor role, but still she’s so pretty.
Merriam D’Abo without IMDB I can’t name the movie I remember her from, but MAN was she cute. Late eighties early nineties. I think she has recently been on Law and Order: CI
Okay, I couldn’t stand not knowing… I IMDBd it. I am thinking of Olivia d’Abo second cousin of Maryam d’Abo (correct spelling). Olivia was the princess on Conan the Destroyer. Maryam was a Bond Girl in The Living Daylights
Couldn’t help myself.
My nomination would be Carrie Henn who played Newt In Aliens. Never worked again.
Adam West did do a Batman feature film in '66.
But did appear twice in the same thread. 
Teri Hatcher has since gone onto Desperate Housewives fame after Lois and Clark, but Dean Cain was pretty much relegated to TV appearances in serial crime shows, as was the main villain (John Shea, playing Lex Luthor).
A Knight’s Tale launched Heath Ledger’s break into stardom, which he’s since validated by Brokeback Mountain, but his leading lady–Shannyn Sossamon–is more famous now for naming her son Audio Science.
Brewster McCloud – Robert Altman’s next film after MAS*H.
My nominee: Chloe Webb, who played one of the two title roles in Sid & Nancy. Gary Oldman was the other, and he’s doing fine, but Webb was in one more film, I think, then fell off the face of Earth, apparently.
Bud Cort suffered a pretty bad road accident in the late 70’s, which iced his career for a while, but he has been coming back, albeit slowly. He was the sleazy restaurant manager in Heat and I seem to remember a pretty big supporting role in The Life Aquatic With Steve Zissou.
Someone wanna fill me in on why we’re not allowed to IMDB things in this thread?
I think the OP wanted us to see what we remembered, not what we could look up.
Jim
She was also one of Drew Barrymore’s friends in Fever Pitch.
And David Herman, who played Michael Bolton in Office Space, was one of the original members of the MadTV cast.