‘Colonization’ of either the Moon or Mars has to happen organically and evolve from real needs and real profits, or it will never happen at all. We are not going to plan and pay for a ‘colony’ as some kind of national project. It would be far too expensive with no commensurate reward.
No, what has to happen is that we need to find things to do in either place that make it economically profitable to go there. That will drive investment and R&D which will eventually solve problems and bring down costs and enhance capabilities.
This is why the Moon is a much better choice for initial exploration than Mars, if what you are looking for is some kind of economy that can sustain continued human presence and expansion.
It’s faster to get to, easier to land on and take off from, and it is riddled with pre-formed habitats - some likely large enough to house major cities if we wanted to.
The moon is close enough to run tele-operated vehicles, opening the door to automated mining and extraction. The lunar regolith is over 40% oxygen. There are abundances of other useful materials like iron, silicon, calcium, aluminum, hydrogen, titanium, etc. All of these things are abundant on Earth as well, naturally, but having them on the moon means that if we do discover some economically valuable activity to do there, we will have the capability to build new things on the moon without having to ship resources from elsewhere.
Also, new research in just the past few years makes the moon a lot more exciting than it used to be. Our post-Apollo picture of the moon was of an essentially dry, airless rock with little to offer anyone and which would need to have basically everything humans need brought to the surface by rocket. However, everything we’ve found from the LROC, GRAIL, LADEE, Chandrayaan and Kuyuga missions has made the moon far more interesting. First we found millions of tons of water ice on the moon (confirmed very recently). Second, we have found evidence that the moon’s interior was/is wet, which not only suggests other volatiles like Nitrogen may be present under the surface, but that the story of the Moon’s creation (and therefore the Earth’s) has some big holes in it. So there is still lots of science to be done on the Moon.
And the story of lunar volatiles is not over - we have detected outgassing on the moon from various places which indicate there could easily be large pockets of volatiles inside the moon.
The GRAIL mission discovered that the lunar crust is about 12% void space. Some of those spaces could be pressurized, some could have liquid or frozen water in them. We just don’t know. We thought we understood the moon well, but it’s turning out to be a lot more interesting than that.
The water situation gets even better, as we’ve discovered that water is constantly being produced on the moon through interaction of the solar wind with the lunar regolith. That water was thought to be released and bounce around the exosphere until it is either dissociated or lands in a cold trap. But now it looks like it might be binding in the regolith in the form of hydroxyl compounds or even water molecules.
Lava tubes aren’t just ‘caves’ that people could live in like moles. They’re more like the size of space colonies - hundreds to thousands of meters wide, and possibly hundreds of kilometers long. Hollow lava domes would be stable up to five kilometers in diameter and over a kilometer high. That’s a ‘cave’ where you would feel like you are outdoors. You could be agoraphobic standing in the middle of that. If we could pressurize it with an atmosphere, you’d have enough space to grow crops, raise animals, and house a million people.
One of the sites that’s most likely for an early lunar exploration base is the Aristarchus Plateau. This plateau is a piece of the old lunar crust pushed up by the force of the impact that created Mare Imbrium. Lava flows from Imbrium then surrounded it, making it look like an island in an ocean almost.
Aristarchus is interesting because there is a hell of a lot of different geology there. Many different rock and mineral types are present, some unidentified. It is covered in pyroclastic materials ejected from ancient volcanic activity that would be especially easy to harvest compared to hard sheet lunar basalts. Aristarchus has been the site of numerous observed ‘outgassing’ events by astronomers on Earth, and also measured by Apollo 15 and the Lunar Prospector mission. It’s also one of the richest regions on the moon for rilles and other volcanic features, which means a likely site for enclosed lava tubes and possible volatile pockets that could be mined.
You can imagine a company going there and finding something valuable, kicking off a race by other companies to also get there and stake claims on other valuable sites.
The path to a potential permanent future in space isn’t a big government project, it’s something more akin to a gold rush. If we can find something worth rushing for. If not, we may get lucky to have a scientific outpost of a few people, and maybe some tourist facility with a few dozsen people coming and going. And that’s about it.
I think it’s more likely that in 50 years there is more human activity in the asteroid belt or the moon or both than there is on Mars.