# Depression
**URL:** https://boards.straightdope.com/t/depression/626670
**Category:** In My Humble Opinion
**Created:** [June 29, 2012, 7:27am UTC](https://boards.straightdope.com/t/depression/626670 "2012-06-29T07:27:46Z")
**Posts on this page:** 4
**Page:** 2
### Author:  [@VinylTurnip](https://boards.straightdope.com/u/VinylTurnip)
#### Post date: [June 29, 2012, 5:50pm UTC](https://boards.straightdope.com/t/depression/626670/21 "2012-06-29T17:50:02Z")
> [@Jennshark](#):
>
> I got off SSRI meds after 18 years and take an RX off-label that has kicked the crap out of my decades-long chronic depression. The psychiatrist I found last year is my goddess!
>
> SSRIs never did much for me and recent research indicates that they don’t work for some people, or the benefits are negligible.\*
Just because I’m curious, do you mind revealing what you’re taking?
I took SSRIs for almost a decade (and quit several years ago) and I’m curious what off-label drugs are also being tried.
---
### Author:  [@Jennshark](https://boards.straightdope.com/u/Jennshark)
#### Post date: [June 29, 2012, 5:57pm UTC](https://boards.straightdope.com/t/depression/626670/22 "2012-06-29T17:57:05Z")
> [@VinylTurnip](#):
>
> Just because I’m curious, do you mind revealing what you’re taking?
>
> I took SSRIs for almost a decade (and quit several years ago) and I’m curious what off-label drugs are also being tried.
Adderall 🙂 I’ve had a near-miraculous response to it and no negative side effects. It’s not an uncommon off-label use for depression, from what I can gather.
---
### Author:  [@Jennshark](https://boards.straightdope.com/u/Jennshark)
#### Post date: [June 29, 2012, 6:01pm UTC](https://boards.straightdope.com/t/depression/626670/23 "2012-06-29T18:01:22Z")
Whoops, premature posting \> theory is that some types of depression respond to norepinephrine and dopamine agents, while other types may be serotonin-involved (SSRI) (I’m being very reductive here).
---
### Author:  [@TruCelt](https://boards.straightdope.com/u/TruCelt)
#### Post date: [June 29, 2012, 8:39pm UTC](https://boards.straightdope.com/t/depression/626670/24 "2012-06-29T20:39:27Z")
Just because your depression is situational does not mean that there is no chemical problem. The body compensates for extreme emotional pain just as it does for physical pain. The brain chemistry does change in many cases, the nervous system depresses response to ease stress. It doesn’t always switch back on it’s own, even after the stressor is gone.
[Previous page](https://boards.straightdope.com/t/depression/626670.md?page=1)