Do purebred cats suffer from genetic diseases as much as purebred dogs?

It is a booklet called Canine Consumer Report, published by “The Association of Veterinarians for Animal Rights”, which is associated with the HSUS.

Where has it been shown that simply because an animal is purebred, particularly a dog, it will have an increased risk of genetic disease? Or, is that it has been shown that more purebreds - far more purebreds - are tested and therefore will show up far more often in lists of both positive and negative results?

If you look at the percentages, mixed breed dogs are not doing all that well. If you go here and search for “Hybrid”, you’ll see that of the hybrids tested, 20% were hip dysplastic, and that is just of the hip xrays that were actually submitted to OFA for review (really bad hips are generally not sent in). Labradoodle percentages are better, but out of the untold thousands of those that have been sold in this country, only 52 of them have had their hip xrays sent to OFA, only 48 elbow xrays and 38 thyroid tests - despite there being labradoodles affected with these three. Goldendoodles aren’t even listed, which means OFA has recieved nothing for those crosses. You have to know enough about what is going on in dog breeding to be able to interpret the stats.

Essentially, we all carry for at least a few genetic diseases. The issue is whether or not linebreeding, which is what all purebred breeding is, “creates” or makes more common any of these diseases. It doesn’t, simply because a breeding program - linebred or “hybrid” - can only produce whatever genes are put into it. Popular breeds tend to have a majority carelessly bred until there are so many sickly members of that breed out there that the popularity crashes and the responsible breeders are left to clean up the mess. Whether those carelessly bred sick dogs were linebred, inbred or outcrossed doesn’t matter, what matters is that the “breeders” didn’t care to do any health checks or to keep their breeding stock healthy - all they cared about was to crank out as many pups as they could, as cheaply as possible.

He specified purebred dogs and cats. The fourth post, from JKilez, claims that “aggressive inbreeding” created sinus and eye problems in Persians. astro linked to a highly emotional and rather questionable site on captive bred white tigers that appears to be trying to blame “incest” for birth defects. Malleus,Incus,Stapes! linked to a site that purports to have a list of genetic diseases of cats, yet under the first breed is listed a physical result of a behavioral problem (Psychogenic alopecia - overgrooming due to stress).

PETA and the HSUS are doing their best to make it impossible for me to continue to breed a litter every two or so years from completely health checked parents with pedigrees containing generations of heath clearances. One major way they are doing this is to put out propaganda convincing the general public that a responsibly bred purebred is the same thing as a mass produced puppy mill pup, and that both are inferior to mixed breeds. This is leading to laws that more and more restrict my ability to even have dogs, much less breed, yet don’t touch big puppy mills like Hunte. So, when I see posts that are blaming a type of breeding (linebreeding, inbreeding, pure breeding) for genetic disease, I try to fight the ignorance!

Certain types of cancers have been associated with specific breeds, or groups of breeds (large breeds, small breeds, terriers, brachycephalics). Those types of cancers can happen in all breeds, but studies have shown again and again that they occur primarily in certain breeds. I’ll go check my references at Pubmed tomorrow. Since these diseases have been associated with certain breeds, some sort of genetic component has been suggested. I’ll have to do a literature review to see if they have been found (remember, the research may be ongoing).

Hip dysplasia is multifactorial, but one thing you have to consider is that most of the bone diseases occur in larger breed dogs. IIRC, the only disease immediately associated with small breeds is avascular necrosis of femoral head. Again, there may be a genetic component as to why larger breed dogs (as a group) are more likely to suffer from those conditions than other medium sized or small breed dogs. Also, if I remember correctly, one of my mentors, with an interest in bone pathology, mentioned some research trying to figure out gene defects as a possible cause for some of those conditions. I’ll have to check her references tomorrow.

Agreed, and this happens not just in dogs, but in other species (cats, horses, cattle).

I answered the OP, and it was his post, not the others, which I answered with my first post. And yes, the conditions I listed ARE associated with different cat breeds. And yes, there are conditions in dogs (not just hip dysplasia or cancer) which ARE associated with specific breeds or types of breeds.

I’m not disputing that there are diseases that are genetic, nor that there are a very few that are pretty much limited to one breed. However, this doesn’t mean that simply because an animal is purebred, it is more likely to suffer from genetic disease than a random-bred one.

In larger dogs period - the breed or lack thereof makes no difference. However, in the case of hip dysplasia, size doesn’t appear to make as much difference as it should. Affenpinschers have a 15% dysplasia rate with OFA, whereas Dobermans only have 6%.

Same here - back when the “apoo” mixes were so popular, many of them were “skippers” due to Legg-Perthes or subluxated stifles.

OFA has done extensive research regarding the genetics of hip dysplasia. I don’t know about any of the others since they do not occur in my breed.

Copper storage disease in Bedlington terriers (and to a lesser degree, and with a different pathogenesis, a couple of other breeds), various types of juvenile nephropathies (kidney diseases), certain heart diseases, etc.

Going back to the topic, I found the following article, from 2008 (sadly, no online abstract available unless your institution is subscribed):

Breed-related disorders of cats
J Small Anim Pract. April 2008;49(4):167-8.
Danièlle Gunn-Moore1, Claire Bessant, Richard Malik

An editorial, it offers other references, and mentions how the defects are not even worldwide, but confined sometimes to particular countries (US vs UK vs Australia vs New Zealand).

Some of the references are old, and some are about conditions which are thought to be linked to a gene:

Hereditary meningoencephalocele in Burmese cats.
Sponenberg DP, Graf-Webster E.
J Hered. 1986 Jan-Feb;77(1):60.

TAKANOSU, M., TAKANOSU, T., SUZUKI, H. & SUZUKI, K. (2008) Incomplete dominant
osteochondrodysplasia in heterozygous Scottish Fold cats. Journal of Small
Animal Practice 49, 170-172

BARRS, V. R., GUNEW,M., FOSTER, S. F., BEATTY, J. A. &MALIK, R. (2001) Prevalence of
autosomal dominant polycystic kidney disease in Persian and related-breeds in
Sydney and Brisbane. Australian Veterinary Journal 4, 257-259

BARTHEZ, P. Y., RIVIER, P. & BEGON, D. (2003) Prevalence of polycystic kidney disease
in Persian and Persian related cats in France. Journal of Feline Medicine
and Surgery 5, 345-347

CANNON,M. J.,MACKAY, A. D., BARR, F. J., RUDORF, H., BRADLEY, K. J. &GRUFFYDD-JONES,
T. J. (2001) Prevalence of polycystic kidney disease in Persian cats in the
United Kingdom. Veterinary Record 149, 409-411

EATON, K. A., BILLER, D. S., DIBARTOLA, S. P., RADIN, M. J. & WELLMAN, M. L. (1997)
Autosomal dominant polycystic kidney disease in Persian and Persian-cross
cats. Veterinary Pathology 34, 117-126

L. A. Lyons, D. S. Biller, C. A. Erdman, M. J. Lipinski, A. E. Young, B. A. Roe, B. Qin, and R. A. Grahn
Feline Polycystic Kidney Disease Mutation Identified in PKD1
J. Am. Soc. Nephrol., October 1, 2004; 15(10): 2548 - 2555.

Check out the rates for hip dysplasia among Maine Coons from the posted 2007 registry ( of 1520 tested cats ). Shockingly high ( to me, anyway ): HD

It sort of makes sense to me - an animal that is heavy bodied for it’s overall size would put a lot of pressure on it’s hips as it is growing up. Doesn’t explain the Affenpinschers tho… :smiley: