…Fat Bastard
Goldmember
Linda Richman (from SNL: “Caw-fee twalk with ‘Powl Bowldwin’…talk amongst yourselves!)”
Is Queeg an anti-hero? I left out various gangsters, too, and a question mark beside Dobbs, but would add Charlie Allnut as one of Bogart’s iconic roles that characterize a theme that runs a little deeper than “shoots,fights, and blows stuff up good,” as each wrestles with what it means to be moral in a crazy world in which the problems of three little people don’t amount to a hill of beans.
Tom Cruise:
Ethan Hunt (Mission Impossible)
Pete “Maverick” Mitchel (Top Gun)
Jack Reacher
Austin Powers
Lestat the Vampire
Les Grossman
Jerry Mcguire
Joel from Risky Business
Lt Daniel “You can’t handle the truth” Kaffee
Vincent from Collateral
Hugo Weaving
Elrond - LOTR + Hobbit series
Mitzi - Priscilla Queens of the Desert
Agent Smith - Matrix series
Red Skull - Captain America
Douglas Jardine - Bodyline tv series
At one time he joked he only did trilogies now.
Robert Duvall
Boo Radley in To Kill a Mockingbird
Ned Pepper in True Grit
Frank Burns in MASH
THX 1138 in THX 1138
Jesse James in The Great Northfield, Minnesota Raid
Frank Harlan in Joe Kidd
Tom Hagen in The Godfather and The Godfather, Part II
Colonel Radl in The Eagle Has Landed
Doctor Watson in The Seven Percent Solution
Colonel Kilgore in Apocalypse Now
Bull Meecham in The Great Santini
Harry Hogge in Days of Thunder
Al Seiber in Geronimo: An American Legend
Robert E. Lee in Gods and Generals
on TV:
Louis Mace in The Outer Limits episode “The Chameleon”
Dwight D. Eisenhower in Ike: The War Years
Joseph Stalin in Stalin
Adolph Eichmann in The Man Who Captured Eichmann
Christopher Lee
Curse of Frankenstein as the creature
Horror of Dracula + 8 other films as Dracula
The Hound of the Baskervilles as Sir Henry
The Mummy as Kharis, the Mummy
Sherlock Holmes and the Deadly Necklace + 2 other films as Holmes
The Face of Fu Manchu + 4 other films as Fu Manchu
Rasputin, the Mad Monk as Raspy
The Three Musketeers + 2 other films as Rochefort
Lord of the Rings + 3 other films as Saruman
Star Wars + 2 other films as Count Dooku
Plus assorted historical figures and Death
Sean Connery was very iconic, just a great actor to watch.
Bond, James Bond
Juan Sánchez-Villalobos Ramírez from Highlander, a film I haven’t seen
Daniel Dravot in The Man Who Would be King, ditto
William of Baskerville in The Name of the Rose
Hm. Except for the first, none of these really match what the OP was looking for. I still think he deserves a mention though
How have we gotten this far in a thread about ICONIC roles, and no one has mentioned Jack Nicholson?
Easy Rider
The Last Detail
Chinatown
One Flew Over the Cuckoo’s Nest
The Shining
The Postman Always Rings Twice
Prizzi’s Honor
The Witches of Eastwick
Batman (his is the best Joker)
Etc. Etc. Etc.
Now that’s an idea. An existential introspective movie about self-hatred. “I’m both the villain, and the hero. I kill, but must also kill myself.”
I sense a workable one-man show.
I think the point of the OP was that each of these iconic roles needed to be played in more than one film. There are lots of actors with long, storied careers with dozens of iconic characters.
Michael Freeman isn’t a star, but he’s played many iconic roles, including Bilbo in the Hobbit movies, Dr. Watson in Sherlock, Arthur Dent in Hitchhiker’s, and CIA agent Everett Ross in a slew of Marvel movies.
Is he the body double for his brother Martin? 
Nitpick: Ford delivers a really good atypical character performance in The Mosquito Coast. Not at all his usual work. But audiences (unfortunately) didn’t turn out, so he made the entirely reasonable but still sad choice to retreat to comfortable convention. If Mosquito Coast had performed at the box office, or if Ford had won an Oscar for it, maybe his career would be different, and we’d have gotten to see what else he’s capable of. Alas.
You left out “V” in V for Vendetta.
Hugh Laurie deserves an honorable mention.
Bertrand Wilberforce Wooster (Jeeves & Wooster)
Prince Regent George / Lieutenant George (Blackadder)
Dr. Gregory House (House)
I’d consider Dustin Hoffman long before many of the relatively young actors mentioned upthread, although I don’t think he’s ever played the same character in two or more films.
Elizabeth Taylor has an impressive list of iconic characters under her belt, including Cleopatra in Cleopatra, Pricilla in Lassie Come Home, Gloria Wandrous in Butterfield 8, Maggie Pollitt in Cat on a Hot Tin Roof, Martha in Who’s Afraid of Virginia Woolf?, Katharina in The Taming of The Shrew, Leslie Benedict in Giant, Velvet Brown in National Velvet, and many others.
I think Taylor’s acting chops were often overlooked by her extreme beauty, but she was a great actress. Her portrayal of Martha in Who’s Afraid of Virginia Woolf? is a masterclass in acting. Brilliant actress; great range.
Alec Guinness for:
(multiple performances)
Obi-Wan Kenobi (3 Star Wars appearances; Oscar nomination)
George Smiley (Tinker, Tailor, Soldier Spy + Smiley’s people)
Kind Hearts and Coronets (he played 9 characters in the film!)
(solo performances)
The Lavender Hill Mob (Oscar nomination)
The Bridge on the River Kwai (Oscar for best actor)
Little Dorrit (Oscar nomination)
I don’t care for the guy, but Tom Hanks has to be up there.
Sir Ian McKellen - Gandalf and Magneto
Sire Patrick Stewart - Picard and Prof X