Although he’s no Harrison Ford, Leslie Nielsen’s characters of Dr. Rumack in the Airplane! movies and Frank Drebin in “The Naked Gun” movies as well as “Police Squad” were pretty iconic.
Surely his characters have been the most quotable.
ETA: According to wiki, Seth MacFarlane is producing another “Naked Gun” movie with Liam Neeson playing Frank Drebin Jr. That should be interesting.
Harold Lloyd made ~200 films (silent and talkies). He was one of the most famous and influential film comedians of the silent era. His bespectacled “glasses” character (a resourceful, ambitious go-getter depicting the zeitgeist of the 1920s-era United States), was featured in most of his films, and I argue that in its day at least, that character was iconic. It may have remained iconic today if Lloyd allowed his films to be broadcast on TV, but he didn’t.
Charlie Chaplin’s Little Tramp character should also be considered.