Hi Glorfindel_31, welcome to the SDMB!
I suggest you read Robert William’s technical response to answer your questions. To summarize:
[ul]
[li] Haldane incorrectly assumed that only one gene can be fixed at a time and that no other changes can accumulate until the ongoing one is fixed. So it doesn’t make any sense to multiply the number of generations by total DNA differences.[/li][li] Haldane made other assumptions (number of generations, reproductive age, reproductive excess, etc.) that were unsubstantiated. Haldane himself said “I am quite aware that my conclusions will probably need drastic revision.”[/li][li] Beneficial mutations that do not require a substantial “cost” were not considered.[/li][/ul]