Some of these improvements are solving problems that didn’t exist until very modern times. I doubt they would be likely to have any impact on genetic fitness until last couple of hundred years or so, and even then many would be of dubious utility.
Caries incidence was vastly lower in paleolithic than in neolithic times. While our dentition probably could use some tweaking — like Der Trihs suggests, a new set of adult teeth every 20 years or so would be spiffy — the real problem is that we eat a lot more carbohydrates, and most of it in forms that greatly promote bacterial growth. This just really wasn’t a problem until very recently in our species’ history.
I don’t have a cite for it, but my orthodontist told me that most traditional cultures have slightly larger and stronger jaws, and he’d be out of a job completely if we all ate more like an ancestral diet due to more chewing on tough foods. He also said that teeth tend to grow straighter under heavy use. This was while fitting me for a post-braces mouth guard/growth stimulator that would have expanded my jaw enough for all the wisdom teeth I had coming in. Basically, I was supposed to bite down on it for a couple of hours every day. I didn’t use it regularly and so have some slight crowding and crookedness, otherwise I would have had enough room for even the wisdom teeth.
Our appetites for food were perfectly suited to our environment for 99.9% of our history. While it would be nice to think you could tweak the system to provide proper feedback with modern foods, it’s arguable that modern foods threw our normal feedback mechanisms into imbalance. In other words, changing our appetite feedback mechanisms is a cure in search of a problem.
We’re still in the very early days of establishing a full model of all the mechanisms (leptin, for instance, wasn’t discovered until 1994) but restricting your diet to those foods that were available in the ancestral human diet, even without intentional caloric restriction, has shown improvements in health indicators and appetite regulation in the few specific studies that have been done so far, and there’s a ton of indirect research into ancestral diets and hunter-gatherer diets that strongly indicate that many diseases we consider normal are byproducts of civilization. Considering how complicated the systems are, I doubt we could do much better by design without unintended consequences.
Overall fertility was much lower for most of our history, and menstruation was much less common than in modern societies. Longer nursing periods (judging by modern hunter-gatherers, around 3 years) provided prophylactic effects, and both high activity rates and periodic caloric restriction can suppress menstrual cycles and fertility rates. First menstruation in modern societies is very early compared to traditional ones too.
Conscious control of fertility would be very cool, but exceedingly unlikely to be of much benefit to our species. If you’re going to tweak things that much, unilateral control of fertility still lying with the female kind of rubs me the wrong way, so to make things fair, both the male and the female having to agree on when mating is for making a baby and when it’s just for fun sounds a lot more equitable. Keep in mind that by doing that you’re going to greatly decrease overall fertility, so any external factors that could cause a population bottleneck might just wipe out even our hardier engineered humans.
I can’t think of any kind of workable mechanism for it besides: seasonal fertility, which is a MAJOR source of conflict in species that have it, so not that desirable considering how violent we are already; something like adding a catalyst gender, which means that one individual either has no genetic input, or functions as a “bit-check” on the DNA code, which may have a very negative impact in low-mutation conditions by restricting diversity; or making everyone hermaphroditic and only practicing reproductive sex when both parters agree to impregnate one of them. No matter what you do, those seemingly simple biological changes are going to have such an enormous impact on what is one of the single strongest universal drives of human cultures that the resulting species probably wouldn’t be recognizably human in behavior.
Cancer appears to be largely a product of modern lifestyles. Diet has a major impact on cancer rates (almost absent among hunter-gatherers) as do fertility patterns (longer nursing, fewer menses have prophylactic effects; again reproductive tissue cancers are virtually absent in traditional cultures.)
Backaches and foot problems are also a product of modern life. Sitting in chairs and shoes are the main culprits, along with abnormally low levels of activity compared to our ancestral norm. More total activity, more squatting or sitting on the floor, and walking and running barefoot as much as possible help alleviate most of these orthopedic problems.
You’ve got to keep in mind that everything, EVERYTHING is a trade-off. For instance, I, as a human male, think having internal testicles would be an awesome idea, but they’re external probably to make it easier to regulate temperature. Changing that one thing would necessitate other cascading changes. Regeneration would be great too, but you’d have to find some way of regulating cell division so that you didn’t inadvertently cause cancer.
If we’re talking about magic science that just solves all the problems of support systems and regulations without any major redesigns in other systems, then my wish list overlaps a bit with Der Trihs and a couple of other people so far.
[ul]
[li]Tougher or more useful finger and toenails, and better anchoring. I’ve had too many torn, broken, and smashed fingernails and toenails in my lifetime. Even toughened with hard use, fingernails don’t develop into decent claws, and are still very breakable. Would have to have no impact on dexterity. Absence would negatively impact dexterity, which is why I’m not arguing for removal. Try picking up a coin or pulling out a hair with fingernails clipped very short and you’ll see what I mean.[/li][li]Regeneration and improved healing. Especially something that better regulates bone reformation. Partial crippling due to broken bones happens even with modern surgical intervention. I ought to know, my wrists were pinned back together several years ago and while I have very close to full recovery, I do still have some slight problems due to the breakage. Without surgery I would have been permanently crippled.[/li][li]An improved immune system. Overlooked by everyone so far, infectious diseases and parasites are responsible for the majority of mortality and morbidity, far beyond anything else except for cancer and heart disease (which as I’ve shown are due largely to lifestyle and diet, and limited almost entirely to industrial societies). Even with all the research we’ve done, infectious diseases are still an enormous problem and we’ve got very little we can do about them.[/li][li]Improved eye design. Retina more akin to cephalopods to avoid blind spot and visual artifacts. More infra-red sensitivity for better night vision. Probably multiple lenses for better acuity in different conditions. Possibly a nictitating membrane for cornea protection.[/li][/ul]
Honestly, given biological constraints, even over such a short term as 8,000 years I don’t see most of these changes as either useful or of being preserved well. I’d bet it’s more likely that we develop nanomedicine that can do replacements of certain tissues and systems in situ in the near future than that we figure out how to code the stuff properly with DNA without causing problems in the long run, and making it inheritable over a time scale of thousands of years without seriously unintended consequences. I mean, most people think the appendix is useless, but by eliminating it, you might kill off some humans just because they can’t recover quickly from a bout of diarrhea.