# Glucosamine for better knees

**URL:** <https://boards.straightdope.com/t/glucosamine-for-better-knees/58072>\
**Category:** Factual Questions\
**Created:** [March 15, 2001, 8:58am UTC](https://boards.straightdope.com/t/glucosamine-for-better-knees/58072 "2001-03-15T08:58:29Z")\
**Posts on this page:** 1\
**Page:** 2

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**Author:** ![barbitu8](https://avatars.discourse-cdn.com/v4/letter/b/839c29/32.png) [@barbitu8](https://boards.straightdope.com/u/barbitu8)\
**Post date:** [March 27, 2001, 3:50pm UTC](https://boards.straightdope.com/t/glucosamine-for-better-knees/58072/21 "2001-03-27T15:50:55Z")

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> [@](#):
>
> \*Originally posted by CrankyAsAnOldMan \*  
> \*\*Anyone up for this same conversation, only about SAM-e? Isn’t it reputed to have similar effects on joints, but with fewer interactions or negative effects? Damned expensive though–buck a dose. \*\*

```
SAM-e contributes to the synthesis and breakdown of serotonin and dopamine, brain chemicals that regulate moods. At least 40 clinical studies offer some support for its use as an antidepressant. More research is needed. (Consumers Report, October 1999)

The most important problem is that SAM is converted into homocysteine in the body, high levels of which may contribute to heart disease (U.of Cal., Berkeley, Wellness Letter, January 2000).
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