The whole epigenetics argument is silly. It’s the logical equivalent of the old creationist “God of the gaps” argument, where they point to a gap in our knowledge that science has not yet filled and declare “Ah ha! GOD must have done that, since so-called ‘science’ cannot explain it!” You’re doing the same thing here. You’ve stumbled upon a new area of research which, unsurprisingly, is as yet poorly understood and declared “Ah ha! GMOs could be using this method to silently kill people, and ‘science’ cannot prove it’s not!” The problem is, you could use this argument on literally anything. My laptop is emitting low levels of radiation, and radiation is known to affect DNA. So we cannot prove that my laptop is not causing epigenetic changes that will give me cancer in 20 years! Let’s ban computers! It’s snowing! Our bodies adapt to temperature changes - what if the cold weather is causing vague, unspecified epigenetic changes that will kill me in 30 years?! Let’s ban cold! And so on, and so on.
Is it possible that GMOs could be causing unknown epigenetic changes with unknown yet vaguely scary consequences? Of course. But “possible” is a very, very low bar to set. There aren’t very many things that aren’t possible at all. It’s possible that there is a race of invisible aliens monitoring our every moves that are getting fed up with reality TV and will destroy the planet if we show one more series of Survivor. We can’t prove they’re not there, after all! Best cancel all reality television just to be safe, or at least until we’ve researched the problem more thoroughly.
So, let’s examine this epigenetics stuff a little more rationally, like thinking beings, and see if there are rational, reasonable reasons to be concerned instead of whipping out the useless “possible” test. Epigenetics - and for the record, my PhD work is tangentially related to epigenetic mechanisms in fruit flies, so while I’m not an expert, I do know something about the subject - is simply a method of gene regulation. Genes get upregulated and downregulated by certain signals. Now, we’ve known about gene regulation for a very very very long time. Our bodies are constantly adjusting and adapting our cellular environment according to a whole host of external signals. The only thing that’s different about epigenetic modifications is that they have the slightly interesting ability to be passed on through time, even from one generation to another. That’s it. So I can turn off a gene in my own body, and pass on that state to my daughter, so she also has it turned off in her body. That’s epigenetics.
So first, why are we discussing epigenetics at all? Surely all forms of genetic regulation are just as potentially problematic. To be clear, we’re talking about something along the lines of a tumor suppressor gene being shut off, or a protooncogene being turned on, which could, in theory, increase your chances of getting cancer later in life. You don’t need epigenetics to do this. Good ol’ fashioned genetic regulation of any flavor could do that job. The only obvious reason to be talking about epigenetics changes is, as I said, because it’s a new field, with lots of scary holes through which to drive fear and uncertainty.
But does it even make sense to worry about our foods causing these sorts of genetic changes? Perhaps. We know that there are dietary influences that can increase (or decrease) cancer rates. Eating too much iron if you have hemochromatosis can cause heart or liver cancer, while diets rich in antioxidents are thought to be somewhat protective. I’m not aware of any epigenetic links between food and cancer, but they might be out there. I’d be surprised, because it seems like a very silly thing for the body to do: “dude just ate some chocolate! Let’s fire up some liver cancer!” but disease doesn’t always make sense.
So the real question, as always, is this: is there any realistic reason to believe that GMOs are more prone to this sort of problem than any other food out there? I certainly can’t think of any, and GMO opponents have never presented any arguments that I find at all compelling. It always boils down to “oh, they’re just so different, and that scares me!” I reiterate a point I made before: we’re not just grabbing random genes and shoving them into our food, hoping that they do cool shit. We know precisely what changes we’re looking to make, and what those changes are supposed to do.
Look: we eat dozens and dozens of species of organisms in a typical diet. Each species has tens of thousands of proteins in it. We’re exposing ourselves on a daily basis to somewhere on the order of hundreds of thousands to millions of different proteins. Now, we take one protein from species A - where we’ve worked with it for years and learned all about it - and put it into species B, and somehow, this tiny blip in the ocean of different proteins is supposed to do all sorts of nasty, unspecified stuff that will kill us all. It’s just ridiculous on the face of it.
Yes, we need to test. Yes, we should be careful. Yes, we should monitor, watch for problems, and investigate anything that looks suspicious. But to say that this technology should be banned, or given scary warnings, or feared, simply because we cannot be 100% certain ahead of time that it will never ever cause any problems of any kind whatsoever - just like every single other invention and technology in the history of the planet - is just silly and childish.