FWIW,
I did a cycle of accutane back during my teen years. It worked extremely well - my skin looked great.
But I just didn’t feel right. Difficult to explain. Just a general overall feeling of unwellness. Nothing terrible, just a constant…not right feeling. I was happy to quit it after a few months.
from wikipedia:
[quote=Depression
Several studies have suggested a possible link between isotretinoin and clinical depression.[16]
[17] However, no conclusive evidence has been produced. Despite this, the argument that isotretinoin caused depression and suicide has won a few lawsuits, and is partially responsible for the strict control of the drug, especially in the United States. Various case reports of depression, suicidal ideation, suicide attempt, and suicide in patients treated with isotretinoin have been reported to the U.S. FDA Adverse Events Reporting System, with 431 cases reported between 1982 and May 2001 – of these 37 patients had committed suicide.[18] While analyses have suggested an association between isotretinoin therapy and depression, no causal relationship has been established and further studies are required.[19][20]
Studies have shown that patients with acne, the population group eligible to receive isotretinoin therapy, have an increased risk of clinical depression compared with the general population.[21][22] Chee Hong describes Isotretinoin-related depression as “an idiosyncratic side-effect”, claiming, often anxiety can bring on acne and depression, creating more anxiety.[23] Correspondingly, treatment of severe acne with isotretinoin has been shown to reduce anxiety and depression, for tests have shown acne to be a main depressant in most tested patients’ lives.[24][25]
One study utilising positron emission tomography (PET) showed functional brain imaging changes in patients treated with isotretinoin, however the clinical relevance of this finding is unclear.[26]
U.S. Representative Bart Stupak (D-MI) is known for his distrust of Accutane. He believes unadvertised psychological side effects from the drug drove his teenage son, Bartholomew Thomas “B.J” Stupak Jr., to commit suicide in 2000.
Psychological effects
In addition to possible anxiety, several studies have shown that male patients taking isotretinoin show increased sensitivity to testosterone, and related psychological effects such as unusual irritability, over-inflated self-confidence and increased sexual desire. It should be noted that none of these symptoms have been known to last more than one month after the end of the treatment. Am J Psychiatry 2007;122(5):996-67. PMID 16363402
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Wikipedia certainly isn’t a proper medical journal so I don’t give it full credibility. But I will say I never felt “right” when I was on accutane. I remember contemplating this “not right” feeling well before I was even aware of any suggested links with Accutane to psychological problems. I know lots of people use it with few or no side effects, and it does work very well at treating acne.
…adult now, I still get mild acne, but it doesn’t bother me much.