Let’s look at the expected value for covering two “dozen” bets – that is, the 1-12, 13-24, 25-36 wagers, or the 1st, 2nd, 3rd column wagers.
Each of these bets covers 12 numbers out of 38, and pays 36 for 12 = 3 for 1, or 2 to 1.
The probability of a win, covering two of these wagers, is 24/38. The probability of a loss is 14/38. Assuming a pair of $10 bets, a win returns $30 ($20 plus the wagered $10), and a loss returns nothing. The expected payout is $30 * 24 / 38 + $0 * 14 / 38 = $18.95
However, it costs you $20 to play this game. The expected value of this strategy is the expected payout less the cost to play the game. EV = EP - C = $18.95 - $20 = -$1.05. Dividing this by the $20 wagered produces an EV percentage of -5.26%.
In conclusion, this strategy expects to lose 5.26% of the total amount wagered on each spin of the wheel, in the long run. This is the house advantage, and with two exceptions, applies to any betting pattern or strategy in American (double-zero) roulette.
For completeness, the exceptions are the even-money wagers where the en prison rule is in effect, with a house advantage of 2.70%, and the 5-number (0, 00, 1, 2, 3) wager, which has a house advantage of over 7%.