I had a Nissan Pathfinder for 26 years before the engine blew up on me. I replaced it with a new Pathfinder. I like the rear-mounted cameras, but all the extra options are overwhelming. If I want to use GPS on my dashboard, I have to have the Bluetooth setting open on my phone. I don’t like doing that, because it keeps fumbling between the FM station on my radio setting and my Spotify app and sending me alerts on my phone when it happens. It’s a bigger learning curve than I bargained for.
I don’t have any experience with Mazda, but you can’t go wrong with the other 3. Honda and Toyota are kinda boring. Appliance-like. I’ve got a couple Nissans that I’m happy with. Easy to work on, but never really needs it. Also quite fond of my Mitsubishi. It’s cheap as a Dixie Cup, but has so much character! The Suzuki is fun, too!
I categorize the four of them into two subgroups. IME, Honda and Toyota are at the top. Both manufacturers produce high quality and reliable vehicles. Mazda and Nissan are a touch below, but also nice. I still carry a grudge against Nissan, though, because in the '80s, my brother bought a Nissan pickup whose paint started peeling and flaking within the first 2-3 years. He appealed to the dealership for some kind of fix, and they basically told him to go kick rocks. IIRC, that was at a time when Nissan had some problem with some paint colors not adhering well, but I don’t remember if it was a process problem, an issue with the paint formulation, or something else, but to me, the most important factor is that they didn’t stand behind their product, and ever since then, we have not considered Nissan when we shopped for cars.
Our family ownership history of the marques is three Toyotas (1st gen Prius with over 400k miles on the clock, 2nd gen 4Runner, early Corolla wagon), two Mazdas (early '90s Miata, 1st gen MPV), three Hondas (two 1st gen Civic SIs, one later model Civic), and two Nissans (late '80s trucks, one 4WD and one 2WD).
Not one of the choices, but we also would consider a Subaru for a next car, particularly if we needed AWD. Between my parents, my brother, and us, we have (or have had) five Subies and all of them have been great vehicles.
To answer the OP, then, it depends on price. We’d pay a premium for a Toyota or Subie compared to the others, assuming they’re all similarly equipped. As for Nissan, we would not consider it unless it costs a lot less than the others.
Honda/Acura or Toyota for me.
I will never own a Nissan again. I had a Rogue where the CVT went out at 8 years/130,000 miles. The warranty was 10 years/120,000 and Nissan wouldn’t cover it. I had a friend who drove the same model just one year newer. Want to guess when the CVT went out on it? If you guessed when the car was 8 years old and had 140,000 miles you would be correct.
U really enjoy driving my Subaru, and it’s the best car I’ve ever had for driving in the snow, but it’s less reliable than any of my Hondas were.
Mostly i haven’t bought a Toyota just because i didn’t like it as much as the comparable Honda, but i test drove the prius, and literally couldn’t see around the A-pillar to merge on the highway from the dealership. I’m sure that was a good car for someone, but there was no way i could buy the car.
I had a Toyota Echo that I drove for 17 years. Bought it new and only gave it up as a trade-in for my current car. It was extremely reliable, got me through some really crazy situations well (including a many hour drive through a horrible ice storm, that thing was a champ). The only reason I moved on from it was that I just really needed something more modern.
My current car is a Chevy. It does great for me. I love the features. Easy to drive, great to park. I’m happy with it.
But between the 4 options in the OP, I would get another Toyota because I feel like I can trust that manufacturer.
Nissan all the way. Bought a King Cab back in 76 and never looked back. I’ve owned a Nissan ever since. Other cars as well, but always a Nissan. Each of my trucks had over 150K miles on them when I traded them in on a new one. My current drive is a 2016 Rogue I bought new. Still has less than 75K miles on it.
My wife’s crappy Nissan only made it 360k! The door handle literally worn out before the head gasket went.
OK, one more anecdotal “data point.” My last car was a 1993 Mazda 626. Manual transmission. Fun to drive. It went just over 330,000 miles in 25 years before I donated it to my local NPR station (though I’m not sure they netted any money on the deal). Original engine (it was burning just a little oil at the end), original clutch, original brakes. Only service it ever needed was oil and filter changes. And some tires, of course. Pretty good run.
You made a wiser decision than me. I was going to buy a ‘92 or ‘93 Mazda 626 to replace my old GLC. Instead my stepfather talked me into buying a 1992 BMW 325is under the military sales program in Germany. I got a good deal at least.
And the car was really fun to drive and looked awesome. I felt like Ferris Bueller driving the Ferrari when I drove it off the lot. (I could hear the Oh Yeah song in my head.) But reliability-wise it was a complete POS. I sold it with just 92K miles on it and no working A/C (because the dealer wanted $3,500 to replace the condenser and wasn’t sure if that would fix it or not). Also the engine had a habit of randomly stalling under acceleration…like in the middle of an intersection. 
Since then I have only owned Japanese models.
Since 1987, my family has only ever owned Toyota//Lexus and Honda/Acura cars. I’d say about a dozen among my dad, sister and me. None has ever died. One Camry was totaled, but all of the other 11 may all still be on the road. I gave away 2 that had surpassed 200k miles. I sold 3 of them, and my dad gave away or sold the others. I gave a 1992 Accord with 300k miles to my neighbor and my sister’s old 250k-mile Civic to a friend. Amazingly durable and reliable cars.
Of course, now my main “car” is a leased Ram truck, although my ‘09 Acura with 250k miles is still my trusty 2nd car.