How long do neurotransmitters take to go through their cycle?

What? When talking about psychoneuroendocrinology, it’s ok if what you have is tentative information. Isn’t it interesting that I found it takes 10 minutes for my mind to wind down and we later found out that this corresponds to 5 half-lives of adrenaline which is the rule of thumb used in medicine for when a substance has been practically eliminated? Maybe it’s a coincidence but isn’t it worth a longer look?

from Adrenaline (Epinephrine) Injection BP 1 in 1000 - Summary of Product Characteristics (SmPC) - (emc) :

“Adrenaline is rapidly inactivated in the body, mostly in the liver by the enzymes catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO). Much of a dose of adrenaline is excreted as metabolites in urine. The plasma half-life is about 2-3 minutes. However, when given by subcutaneous or intramuscular injection, local vasoconstriction may delay absorption so that the effects may last longer than the half-life suggests.”