If the IBS symptoms occurred after ending the use of antidepressants, then have her try going back on the antidepressants.
WebMD gives a list of antidepressants that might be prescribed. I take venlafaxine for my IBS. Not a cure, but it made it far more tolerable day-to-day. Side effects are minimized since I use much less than a dosage therapeutic for depression.
Of course, she needs to talk to her doctor before resuming a med like this. You also don’t specifically mention if she’s seen a specialist gastroenterologist. If she hasn’t, I’d strongly recommend one.
Has she been tested for celiacs?
She does not happen to have E-sure implants by any chance?
FYI, this is a zombie thread. Still plenty of helpful information, though.
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As long as we’re reviving this zombie, there actually is an objective test for IBS. I have been tested for it and so has my son. There are several “markers” that show up in a blood test. I had the minimal number for a diagnosis, which was, IIRC, four. That works very neatly with the “mild” IBS I was diagnosed with years ago based on symptoms, before the test existed. My son has only one. So he didn’t get the diagnosis, but it was enough for his doctor to write a note to his school saying that he did not need to be sent home for a single instance of diarrhea (their policy) unless he also had a fever. We had him tested after he was sent home three times in one month, and we were giving him a dose of Imodium every school morning so it wouldn’t happen, while a culture of his stool found nothing, and he never had a fever.
Anyway, when the thread was first posted, the test may not have existed, because it is relatively new. So I thought if someone besides the OP clicks on it, it would be useful to have the info. I assume that by now the OP has a solution. At least I hope.