Been in the employment field for 25+ years. Listing a PO Box is not an issue, that is until a street address is needed is an hire package is expressed via FedEx, or the like. After all, there are locations where mail delivery is only via PO Box.
What you could do is list both a mailing address and street address.
Glory, the advantage to listing an address at all - Databases and the way they search based on location and/or zip-code.