This will vary DRAMATICALLY with the drag coefficient of the car. The more aerodynamic the vehicle, the more the disruption is going to affect the fuel economy. A pickup truck will have a much lower impact of having windows rolled down than a small sports sedan will. And you’re just pulling numbers out of your rear at this point.
In the early 2000s, I drove a Dodge Intrepid 30 miles to work each day. On the days I could stand it, I used the 4/65 cooling method – 4 windows down, 65mph – and it was notably more efficient by a few MPG than running the AC