To be frank, I’d probably not answer that question honestly as a hiring manager. Has one ever given you concrete concerns when you’ve asked that question?
A better question to ask might be “Is there anything about my qualifications for this job I can clarify or expand on?”.
No, but then I only formulated this question during my recent job search, and I got the job (and the question was received well, and thoughtfully), so I guess I don’t have any examples of when it worked badly.