I like this, but I would make a few changes. The bratty one should be either a bongo or a tambourine. The good transformers are somewhere between the Partridge Family and the Monkies, and the deceptacon band is a heavy metal goth band.
It may be time to dust off the script for Mohammed and the Professor.
Hijinks ensue when Mohammed himself returns to earth, and needs to take a job as a valet to a Professor at a major American university.
To avoid any possibility of offense, the actor playing Mohammed will never actually appear on-screen.
Chalk me up as someone who would watch Scrotes and Goats.
George Carlin had a good one awhile back: The All-Suicide Channel. Real-life suicides and America votes on who comes up with the most creative way to do it. It would be the most-watched show in history, behind Scrotes and Goats, that is.
Clearly, the lead-in show to Scrotes and Goatse.
How about: “Blue Men”. A sitcom based on the life of William Wallace, with Wallace played by none other than … Wallace Shawn! It would be funny because Wallace Shawn is so different from William Wallace … yet they’re both named Wallace!
A real dumb guy (like Johnny Carson’s Floyd Turbo) - a fat! real dumb guy, but not a decent at heart, hard working, salt of the earth dumb guy but a real putz - an unemployed, hard drinking, bitter teabagger type with a big mouth and opinions about absolutely everything - finds himself elected President of the United States of America. Over to you, Floyd! Hilarity ensues.
I read this wrong first time around. I thought you meant the twins would be played by Mary-Kate and Danny DeVito. Which I think is workable 
The OP wants sitcoms, not historical documentaries.
I Got Yer Sitcom Right Here, Pal
Wallace Shawn and Danny DeVito sitting at a used desk, on chairs from Goodwill.
Sort of an urban Red Green Show. People come, people go, stuff breaks, minor psychodrama ensues.
Too meta?
Better yet, a Republican with a house on Martha’s Vineyard.
Working title: Gay Head.
Mr. Crowley’s Neighborhood.
In which King Friday 13th decides to remove Sarah Saturday’s head after he notices she’s gotten a little too friendly with the goat family.
BUTTHEAD
His mom did lots of drugs during his pregnancy - and now Asewipe actually has a butt growing out of his head. He’s brilliant, he’s charming, and occasionally he farts while he talks!
Hilarity ensues.
Pee-Pee Puppet Palooza.
I think this one is self-explanatory.
How about this one: It is set in a nursing home…the old men start having affairs with the female inmates…mayhem ensues!
I’ll call it “Everybody Loves…Dang…Who Was That?”
Or, you change this to a prison, and the old man is the bitch of Cellblock C. And the title is “Everbody Loves Prisoner #90210”.
Who’s Your Daddy? starring Mackenzie Phillips.
The sketch comedy group The Whitest Kids You Know did a skit on this topic. It was spoofing American Idol but the contestants were committing suicide. The Simon Cowel character was hilarious as he was unimpressed with the more “normal” suicides and was telling the newly dead people things like, “I’m sorry but that was horrible you’ll need to try much harder next time.” and when one guy really impressed him he says, “That was brilliant I can’t wait to see what you come up with as you’re going to Hollywood!”
Ummm . . . is that Wil Forte playing Hitler? Sure that isn’t an SNL sketch?
Are any of these suggestions really stupider than what Fox has already aired? I remember Women In Prison: In the pilot, a bimbo’s lawyer boyfriend dumped her by framing her for a theft and then deliberately botching her defense.