Murderer/body snatcher Ed Gein has been directly portrayed in at least 4 film and inspired numerous characters in multiple other films including:
Norman Bates in Psycho
Leatherface in The Texas Chainsaw Massacre
Buffalo Bill in The Silence of The Lambs
among others.
I just ran across another person who belongs in this thread; Louis Howe, a journalist and advisor to Franklin Roosevelt. To quote from his Wikipedia page:
I literally was about to post this.
My legs ain’t what they used to be be kiddo.
That wouldn’t be the last time that a cowboy has killed God Almighty:
Edward Teach a.k.a. Blackbeard.
Blackbeard has appeared in numerous movies over the years and on television shows including Dr. Who, Black Sails, and Our Flag Means Death. While it’s safe to say that most of us know of Blackbeard, in the grand scheme of things he’s a minor, if colorful, figure. He wasn’t even the most successful pirate of his era.
Most movies about Custer include Reno and Benteen, historical footnotes portrayed by recognizable actors such as William Daniels, Daren McGavin, Jeffrey Hunter, and David Strathairn.
G. Gordon Liddy. A minor member of the Nixon administration and a second-level figure in the Watergate scandal. But he gathered a lot of public attention by being a colorful character.
Played by:
Robert Conrad - Will
William Daniels - Blind Ambition
John Diehl - Nixon
Harry Shearer - Dick
Justin Theroux - White House Plumbers
Shea Whigham - Gaslit
How about Pontius Pilate, played memorably by Rod Steiger in Jesus of Nazareth?
“Handsome Jack” Myers, portrayed in 55 Days at Peking by *Charleton Heston, and The Wind and the Lion by Steve Kanaly.
(*not to be confused with Cluck Heston, who starred in 55 Days at Pecking)
Most of the following are films featuring Charles Maurice de Talleyrand-Périgord as a character:
According to Wiki, Ira Hayes…
Appeared as himself in the 1949 film Sands of Iwo Jima.
Was played by Lee Marvin In the 1960 telefilm The American.
Was played by Tony Curtis in the 1961 film The Outsider.
Was played by Adam Beach in the 2006 movie Flags of Our Fathers.
Michael Palin
Not sure I’d call him a minor figure. He’s sort of my favorite character from the whole period. He is basically a French Blackadder (I am actually rather upset they didn’t feature him in Blackadder the Third, as Rowan Atkinson playing Blackadder with a French accent)
Definitely not a minor figure IMO. If you are mentioned by name in the Bible and especially in one of the most famous parts of the Bible, that makes you one of the most famous people who ever lived.
Yeah, but he’s only famous for one thing. If he hadn’t done it, he’d be of interest only to historians of Ancient Rome.
Careful, or I’ll knock you wuffly to the gwound! 
No, he was a real person, but we do not really know his name.
Yeah, especially Bonnie & Clyde with Faye Dunaway playing the very plain Bonnie.
Also Captain Kidd, who may not even have been a pirate.
Good one.
Yeah, and until recently, there was debate he even existed, as no official roman records or hitories (not that many records were left actually despite the fact that the Roman kept a lot) even mention his name. The same sort of disputed sources mentioned him- the Gospels, Josephus, Tacitus has a brief mention, etc. But they recently (well, 1961) found a stone with an inscription that mentioned him.
Pilate is famous solely due to being mentioned in the Gospels. The ancient Romans didnt think he was worth mentioning. He was a governor of a minor province, and not for very long either. Maybe a decade, but that is argued.
So, if he hadnt been part of the Gospels, even Experts in Ancient Roman history would go 'who"?
I’ve read he was recalled to Rome not long after the Crucifixion and executed for pissing off the Emperor about something. There really is no evidence for this?
PONTIUS WAS HERE
Scholars are puzzled as to why a little man with a bald head and a long nose was etched alongside the inscription.