Yes, most action genres feature preternaturally tough characters. I played with the idea back when City of Heroes was live, with a Natural origin character. He wasn’t a mutant or scientifically modified, and he didn’t get his powers from alphatech or magic. He was just from an alternate universe where civilization followed a different path, and a long-term genetic optimization program had resulted in virtually the entire population of baseline humans having near Wolverine-like regenerative abilities. Half the fun was in pondering the implications of a population like that, particularly in terms of crime and law enforcement. How differently is battery treated when the injuries heal within seconds? Does it mean practically all murders have to be considered premeditated, given the difficulty of actually killing someone with powers like that? What kind of weapons get used on either side of the law when gunshot wounds are just temporary nuisances?
I also got into fun questions like “What constitutes an extreme sport in a world of Wolverines?”