Most Destructive Hand-To-Hand Weapon?

IIRC, Mack Reynolds relays that reasoning in a novel where such a trench knife is the weapon of choice for a modern-day gladiator. (Who promptly loses, one-on-one, to a guy wielding a boar spear, but, hey, it was a pretty good plan.)

Obviously the most powerful hand to hand weapon is a shark stick. Powerhead (firearm) - Wikipedia

The most powerful weapon of all is training.

Ith’ actually a buck-and-a-quarter thtaff, but I’m not about to tell HIM that!

One thing I haven’t seen mentioned in the thread is the classic sling. In the hands of a skilled user, very deadly at a significant range. David basically brought a handgun to Goliath’s knife fight.