Oh, what a timely thread – I just yesterday decided to replay Call of Cthulhu: Dark Corners of the Earth, which I think is an outstanding game, but which also features one of the most frustrating sequences in any game I recall. Right after you found lodging in some charming little seaside town called Innsmouth, where something fishy’s going on, the townsfolk decide that they do not take kindly to strangers, and come battering on your hotel room door – OK, so I was smart enough to bolt that, no problem. But, they burst through after about three or four seconds, so as soon as you hear the first knock on the door, you have to jump up, run to the next room (which you already have bolted shut in advance, but hopefully not closed the connecting door to, because having to take the time to open it will likely leave you as bait for the Innsmouthians), close the door behind you, bolt it shut, careful to not accidentally re-open it instead, which happens about every other time when you’re not precisely facing the bolt, push a shelf away from the door to the next room which you can only do at an atrociously slow pace, open that door, run through, again bolt it shut, run to that room’s door, bolt it shut, again run into the next room, find out that that one’s lock is broken (or rather, you pretty much have to know that in advance, if you have to take the time to check, you’re pretty much dead), push a shelf in front of it which you won’t make fast enough half the time, then race to the window, push another shelf away from it, open it, jump across the balcony, dodge the shots of about two dozen fish, er, men, and then the real hide, seek and flee sequence starts.
The best part, the game has rather sparingly placed save points, so if at any one point you don’t perform your memorized moves perfectly, you have to do everything all over again (though they’ve made an effort to have the save points make sense – they’re mystical signs, and if you’re killed, you get the impression it was all ‘just a dream’, your character is plagued by constant visions anyway).
You do get a gun, eventually, but much too late to really take out your frustration on the townsfolk.
Here’s a video of the sequence (warning, rather graphically violent in places).