This is the sad truth: If profits can’t be made, a therapy candidate won’t be developed. In a fiercely competative market, pharmaceutical companies approach cures like any other business, which can seem fairly appalling when given a summary evaluation. I can’t justify the direct-to-consumer marketing, which I think is probably the ugliest aspect of the capitalistic nature of the industry, and should be banned; but with a lot of other decisions, I’ve come to trust the folks in the suits a bit more (which is not to say some of my idealism hasn’t been sacrificed in the process). Pharma isn’t running a charity, so there’s no reason to expect the sector to behave like one. You give to much away, you go under; it’s as simple as that. If all drug research were publically funded, the world would probably be a better place; but the reality is a considerable proportion of drug development costs are borne by for-profit, publically-traded interests that are beholden to shareholders for returns on investments. It’s fully in accordance with our capitalistic economy: Investment fuels development, which produces a product that generates revenue. If everything goes well, the patient gets a cure, and the investor gets capitol gains. Everybody wins, in theory. In practise, it’s imperfect.
As flawed as the regulated pharmaceutical industry is, the supplement industry is like the Wild West, complete with the flim-flammers and the snake-oilers. Supplement peddlers sidestep the costs of R&D and clinical trials; so, while cheap, their products have no validation. They may be efficacious, they may not. Since they’re not rigorously tested, there’s no way to know. Some can cite peer-reviewed articles supporting the hypothesis that some-or-other substance is good for what ails you, but it is exceedingly rare that such preliminary studies are even remotely adequate as reasonable proof of efficacy. Typically these studies are flawed in design, and even if well-designed and controlled, too small to be significant. I’m not aware of many popular supplements that have been subjected to properly designed and sufficiently large double-blinded, placebo-controlled trials. One that I can think of offhand, St. John’s Wort, turned out to be no better than placebo at curing major depressive disorder, and much better than placebo at giving people adverse dematological reactions. Add to that the fact that SJ’sW radically alters hepatic drug metabolism, and I’d say there’s there’s every reason not to take it, and no good reason to waste your money on it. Similar results were found for echinacea, in regards to demonstrable lack of efficacy, coupled with demonstrable increase in adverse effects (skin rashes, mostly) over control. Ginko is an antithrombotic; ephedra gives people heart attacks and strokes; so where to the supplement-pushers get off saying their products are safer and more effective than FDA-approved drugs? They have no real idea; chances are, they’re lying or bending the truth considerably. They simly can’t be trusted, even when they mean well.
It’s worth noting that even with a fairly robust regulatory system (some even argue its too restrictive), serious negative side-effects from fully FDA-approved drugs can show up years later. Clinical trials simply cannot cover all posible adversities, so even with the best science (which the standard trials we subject drugs to certainly are not), you can never know for absolute certain if a drug you take is safe. But at least the process of investigation makes you aware of the risks. The supplement marketers ask their consumers to simply believe what they say, and in the absence of rigorous scrutiny, it would appear that consumers are only too willing to oblige. So, if the science is out-of-site (because it doesn’t exist), the risks are out-of-mind? As far as I can tell, that’s an accurrate assessment of the sophistication of the average supplement consumer. It’s too bad people take such an irrational approach to healing: Scientists try to be up front about the risks of drugs, so the consumer is paranoid about them; meanwhile the snake-oilers claim “natural”=“safe”, so people seek to take comfort in this fallacy, rather than acknowledge it’s a complicated world.