# Neuroleptic **URL:** \ **Category:** Factual Questions\ **Created:** [March 23, 2021, 1:48pm UTC](https://boards.straightdope.com/t/neuroleptic/938492 "2021-03-23T13:48:02Z")\ **Posts on this page:** 9\ **Page:** 1
**Author:** ![Red59145](https://avatars.discourse-cdn.com/v4/letter/r/d6d6ee/32.png) [@Red59145](https://boards.straightdope.com/u/Red59145)\ **Post date:** [March 23, 2021, 1:48pm UTC](https://boards.straightdope.com/t/neuroleptic/938492/1 "2021-03-23T13:48:02Z")
What is the most effective neuroleptic for schizophrenia ? ---
**Author:** ![Qadgop\_the\_Mercotan](https://sea3.discourse-cdn.com/straightdope/user_avatar/boards.straightdope.com/qadgop_the_mercotan/32/83_2.png) [@Qadgop\_the\_Mercotan](https://boards.straightdope.com/u/Qadgop_the_Mercotan)\ **Post date:** [March 23, 2021, 1:53pm UTC](https://boards.straightdope.com/t/neuroleptic/938492/2 "2021-03-23T13:53:53Z")
There’s no simple answer to that question. The most effective one is whichever one relieves the patient’s symptoms adequately with the fewest side effects that the patient is also willing/able to take as directed. Lots of various effective meds fail to meet those particular qualifications for individual patients. ---
**Author:** ![Colibri](https://sea3.discourse-cdn.com/straightdope/user_avatar/boards.straightdope.com/colibri/32/1841_2.png) [@Colibri](https://boards.straightdope.com/u/Colibri)\ **Post date:** [March 23, 2021, 1:57pm UTC](https://boards.straightdope.com/t/neuroleptic/938492/3 "2021-03-23T13:57:03Z")
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**Author:** ![Colibri](https://sea3.discourse-cdn.com/straightdope/user_avatar/boards.straightdope.com/colibri/32/1841_2.png) [@Colibri](https://boards.straightdope.com/u/Colibri)\ **Post date:** [March 23, 2021, 1:58pm UTC](https://boards.straightdope.com/t/neuroleptic/938492/4 "2021-03-23T13:58:07Z")
I think this isn’t something to be asking about on a anonymous message board. ---
**Author:** ![Colibri](https://sea3.discourse-cdn.com/straightdope/user_avatar/boards.straightdope.com/colibri/32/1841_2.png) [@Colibri](https://boards.straightdope.com/u/Colibri)\ **Post date:** [March 23, 2021, 2:25pm UTC](https://boards.straightdope.com/t/neuroleptic/938492/5 "2021-03-23T14:25:38Z")
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**Author:** ![Colibri](https://sea3.discourse-cdn.com/straightdope/user_avatar/boards.straightdope.com/colibri/32/1841_2.png) [@Colibri](https://boards.straightdope.com/u/Colibri)\ **Post date:** [March 23, 2021, 2:26pm UTC](https://boards.straightdope.com/t/neuroleptic/938492/6 "2021-03-23T14:26:02Z")
Reopened by request. ---
**Author:** ![BippityBoppityBoo](https://sea3.discourse-cdn.com/straightdope/user_avatar/boards.straightdope.com/bippityboppityboo/32/5745_2.png) [@BippityBoppityBoo](https://boards.straightdope.com/u/BippityBoppityBoo)\ **Post date:** [March 24, 2021, 4:35am UTC](https://boards.straightdope.com/t/neuroleptic/938492/7 "2021-03-24T04:35:00Z")
> [@Qadgop\_the\_Mercotan](#): > > The most effective one is whichever one relieves the patient’s symptoms adequately with the fewest side effects that the patient is also willing/able to take as directed. Lots of various effective meds fail to meet those particular qualifications for individual patients. Nothing more to add except +whichever one the insurance pay for or will authorize or is in their formulary. If the person is self-pay then it might need to be one of the older first or second generation anti-psychotics. An insurance company may require trying and failing with one or two first gen anti-psychotics before they will pay for a newer second generation one. ---
**Author:** ![Squink](https://avatars.discourse-cdn.com/v4/letter/s/b5e925/32.png) [@Squink](https://boards.straightdope.com/u/Squink)\ **Post date:** [March 24, 2021, 6:25pm UTC](https://boards.straightdope.com/t/neuroleptic/938492/8 "2021-03-24T18:25:59Z")
You have to watch the cytochrome P 450’s with many of the neuroleptics. [2D-6 in particular](https://testdirectory.questdiagnostics.com/test/test-detail/10490/cytochrome-p450-2d6-genotype?cc=MASTER) can cause a lot of trouble ---
**Author:** ![DavidNRockies](https://sea3.discourse-cdn.com/straightdope/user_avatar/boards.straightdope.com/davidnrockies/32/6279_2.png) [@DavidNRockies](https://boards.straightdope.com/u/DavidNRockies)\ **Post date:** [March 24, 2021, 6:51pm UTC](https://boards.straightdope.com/t/neuroleptic/938492/9 "2021-03-24T18:51:11Z")
Just as an aside … It’s also prudent to avoid grapefruit and grapefruit juice when you’re taking such a medication: > **[Grapefruit–drug interactions](https://en.wikipedia.org/wiki/Grapefruit%E2%80%93drug_interactions)** > > Pages for logged out editors learn more > > > Some fruit juices and fruits can interact with numerous drugs, in many cases causing adverse effects. The effect is most studied with grapefruit and grapefruit juice, but similar effects have been observed with certain other citrus fruits. > The effect was first discovered accidentally in 1991, when a test of drug interactions with alcohol used grapefruit juice to hide the taste of the ethanol. A 2005 medical review advised patients to avoid all...