Anecdotally, it has for me, but I’m not a heavy player — only 30 hours so far. But it ran fine even before all the patches and my current machine. I played it mostly at 1.0 release state, on a GeForce Now virtual machine (unknown how much RAM that has, but probably not 64). My cities were just normal sized though, like however much the base game lets you expand to without mods. I also only ran a few mods (like 6-8, I think). Mostly I played it to import my real-world city as a terrain map, traced over it and added real neighborhoods and then trams everywhere, lol. Going ginormous was never my goal.
We do have another poster here who DOES play that game a lot… I just can’t remember who off the top of my head 
Maybe Askance or msmith537 over at Cities: Skylines II is out ? (That’s what AI says, anyway) IIRC, Askance works on the Cities Skylines 2 team in some capacity.