That would be prostitution, wouldn’t it?
This. There is a branch of The Bay less than a mile from where I live and one downtown too.
Although not a business, McGill will celebrate its 200th anniversary next year.
Looks like the oldest US Business might be Tuttle Farm in Dover, NH. It was founded by John Tuttle between** 1635 and 1638.**
The oldest Company in the World might be: Kongo Gumi in Osaka, Japan est. 578 AD.
Some of the oldest European businesses are of course Breweries.
Good table in this article: The Oldest Companies Still Operating Today - WorldAtlas
In my immediate area, it’s probably this place which has apparently been a bar since 1829. In NYC, it might be Fraunces Tavern which has apparently been operating since 1762.
At that age, I doubt she’s getting much business.
Not even close, Bro. The Lobero Theater dates to 1873. It was rebuilt in 1924 so it’s still older than Joe’s if you only count the current structure. There has been live music in the same spot longer than anywhere in California.
The Mission probably doesn’t count but it started operations in 1786.
I don’t know if they qualify as “businesses” but a few churches here in California’s 49er Gold Rush country have been operating since circa 1850.
Churches do not count.
I don’t know the oldest business in the area, but The Horseshoe Café is the oldest restaurant in the state.
Probably The Bingley Arms
I looked up Cambridge Univ. press and it’s a little bit older than Oxford press , it was founded in 1534
The school that my kids go to was established before the birth of Shakespeare.
The Lake Champlain Transportation Company has been in business since at least 120. They operate three out of four ferry lines connecting Vermont and upstate New York.
By American standards, that’s an old company.
120? That’s old by anyone’s standards! 
Considering that they apparently predate America itself by about 1600 years, I’d agree with you.
I’d guess the answer to the question depends on whether or not you mean headquartered here, or actually had its genesis here. And in the second case, I’d guess that would be dependent on what “here” means.
Headquarters-wise, it’s the AH Belo company, which was originally founded in 1842 in Galveston as the* Galveston Daily News *(oldest newspaper in Texas), and through mergers and whatever else, became a large media conglomerate.
As for local businesses, it’s a company called “Triple/S Dynamics”, which was originally Sutton & Steele in 1888, and originally developed some sort of industrial equipment called a gravity separator or dry concentrator. There are quite a few that are slightly younger- Rudolph’s Meat Market is one that dates from around 1895-ish and is in the same block, if not building that it’s always been in.
Here in the Chicago area, so far as I can ascertain, it’s also a jeweler. C.D. Peacock Jewelers, since 1837.
In my little village in Scotland the two oldest continually-operating businesses only date back to the late 18th-century - both coaching inns to start with, and both still in the same line of business today (well, not actual today, because y’know). There’s a couple of older buildings that used to be mills or whatever, but they’ve been repurposed as housing. Quite a New Town, as these things go.
If it counts as a “business” because it can be visited as part of a museum, that would probably be the Fort Pitt Blockhouse, built in 1764 as part of Fort Pitt.
Out in Leesburg, there’s an engineering firm which predates the Revolutionary War by about 30 years.