[QUOTE=mnemosyne]
It isn’t always (or even usually, IME) true that the generics are made “by the same company on the same machines as the brand names”. There are entire companies out there that do nothing BUT make generic versions of pharmaceuticals - Apotex, Sandoz (although they are a sub-set of Novartis), and Pharmascience are three that come to mind (mainly because I’ve recently applied to work at all of them!)
It is, however, true that they exact same manufacturing, analytical testing and clinical requirements are enforced for the manufacturing of these generic drugs. These facilities must meet the same standards as the brand name companies in the eyes of the FDA, HPFBI (Canada) and/or European/Asian authorities depending on their intended markets. For known, off-patent drugs (which really is what generics are), there are established rules on exactly how the drug product is to be made and tested (USP, EP, JP), what does and does not constitute a “pass”, and any deviation from these methods is a serious problem.
In fact, because generic manufacturers do not have the power of the brand name company behind them when it comes to quality control and good media coverage, they tend to be even more careful about making sure that absolutely everything is correct and within all the known rules, regulations and guidelines. I used to work for a contract manufacturer, which made both generics and brandnames on behalf of other companies, and trust me, they went above and beyond when it came to auditing their own work and ensuring compliance.
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Yup. I used to work for a company that manufactured only generic prescription drugs–Purepac in Elizabeth, NJ. I had access to and involvement with all parts of the operation, and I have full confidence in the quality and effectiveness of the generics.
Mnemosyne makes a good point about how the generic manufacturers can’t rely on the power of the brand name. Another factor that promotes quality is that there is only one company making a particular on-patent drug, so the pharmacies are forced to deal with that company. But there are any number of companies that can produce a generic, so if there is a problem with one, the pharmacy can easily switch.*
*Getting all the approvals needed to produce the generic drug is an incredibly complex and time-consuming process, so it’s not like a generic drug company can just start pumping out the paroxetine. But with a popular drug like paroxetine (Paxil), you can bet that many of the generic companies got approved ASAP so they could get a slice of that profitable pie.