This was addressed in another thread. Antimatter is all but unusable as a fuel, most of the reaction product is neutrinos, which you simply cannot control (they exit in all directions, ignoring almost everything around them. You simply could not contain an adequate mass of antimatter fuel to be useful.
But space is just loaded with free energy, and no matter whether you carry automatons or wetware, you basically have to use it. Your vessel would have a really, really large magnetic field to capture the energy of cosmic rays through deceleration, which not only protects your payload but also supplies you with additional matter, which could possibly be fused for more energy or collected for thrust-out.
The drive/nav system is a tech we are not close to developing, but it would apply force by creating an imbalance in the local vacuum energy density. Captured space energy would provide power for the drive, which would probably not work as well close to large bodies or systems, but in the end, the idea that a starship would need to be, or even that it could be mostly fuel is a bit questionable.
In any case, it is not at all obvious what could be expected of interstellar travelers, their abilities and their motivations. We cannot just project what we know of social behavior outside the bounds of where we have been able to observe social behavior. But I am pretty confident that interstellar society would not look like the Klingon Empire, the Sith Empire, the Saurdukar Empire or any other kind of structure that would look familiar to us.