Dr. Vincent DiMiao, in his book Gunshot Wounds, documents a case where a man was shot in the heart at a range of 3-4 ft with a 12ga shotgun firing #7.5 birdshot. The guy’s heart was shredded, but he turned and ran 65 feet before collapsing. If anything is going to stop you in your tracks, you would hope that would be on the list.
Anecdotally, I was at a wound ballistics seminar, and I heard a police officer relate the tale of a suspect who was holding a shotgun on two people. The police sniper fired a .223 bullet that pierced the man’s heart. He was still able to fire the shotgun at one person, rack the slide, and was preparing to fire again when the sniper put a second shot into his head.