Skyrim mods for first runthrough

A necessity if, like me, you suffer from minor color-blindness.

i haven’t tried any, but if you search for “sort”, there are a lot of mods that rename items so you can easier find them. not sure if they take secondary effects into account.

I would say that full-blown mods are unnecessary for a first playthrough. What I would recommend is a few of the console commands for a few quality-of-life improvements. Something along the lines of:

player.modav carryweight 9900

will let you loot and plunder to your heart’s content without constantly getting encumbered and needing to either pass up loot or head back to town to sell things.

or you could use Bandolier - Bags and Pouches, a simple armor mod to add inventory space.