# Soy and hexane - dangerous?
**URL:** https://boards.straightdope.com/t/soy-and-hexane-dangerous/570497
**Category:** Factual Questions
**Created:** [February 7, 2011, 7:49am UTC](https://boards.straightdope.com/t/soy-and-hexane-dangerous/570497 "2011-02-07T07:49:42Z")
**Posts on this page:** 16
**Page:** 1
### Author:  [@Reply](https://boards.straightdope.com/u/Reply)
#### Post date: [February 7, 2011, 7:49am UTC](https://boards.straightdope.com/t/soy-and-hexane-dangerous/570497/1 "2011-02-07T07:49:42Z")
So I just saw a report talking about how hexane is used in soy protein isolate production – it separates the fats from the protein, apparently, and is then steamed out of the final food product. This concerns me because I eat quite a bit of the stuff. The report and [video](http://www.youtube.com/watch?v=9xDkDpUJ6ug&feature=player_embedded#at=100) struck me as alarmist, but I think I lack the science background to fully understand what’s going on. Wanna help fight my ignorance?
I can’t seem to access the original report (by the Cornucopia Institute), but this [Slate article](http://www.slate.com/id/2252002/) gives a good bit of background.
This is what I believe is true: Hexane IS used in the process, most of it is steamed out (leaving up to 20-ish parts per million in the final product), and what little remains has shown no noticeable effect in lab rats over their lifespans. On the other hand, the long-term effect on human health at that dosage has not been established; the EPA is basically taking a we-don’t-know-so-we’ll-assume-it’s-safe approach.
So:
1. Does that seem about right or am I missing something?
2. Does soy protein isolate/textured vegetable protein/textured soy protein (damned if I know what the differences are) _necessarily_ go through this hexane-laden process?
3. Who is the Cornucopia Institute? Should I have heard of them? Their website doesn’t seem to be working for me and they seem to have come out of nowhere to focus on this issue.
4. How is the international community responding to this? Does anyone care?
5. Can hexane be included in organic foods? (I THINK it can’t be in 100% organic food, but CAN be AN ingredient in less-than-100% organic products). Clif Bar is one example of this and their [back-and-forth with the Cornucopia Institute](http://www.clifbar.com/blog/detail/from_the_field_to_the_table/) doesn’t really clarify the situation much.
Thank you!
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### Author:  [@Jackmannii](https://boards.straightdope.com/u/Jackmannii)
#### Post date: [February 7, 2011, 2:10pm UTC](https://boards.straightdope.com/t/soy-and-hexane-dangerous/570497/2 "2011-02-07T14:10:20Z")
The Cornucopia Institute’s announced goals are to benefit organic farmers, and it doesn’t look like they’re sponsoring any research into how soy meal is processed, just repeating a warning about how Hexane Is A Petrochemical Neurotoxin.
It’s easy to point out how some chemical or other is Toxic, without providing the all-important information about dose. Otherwise you can start sounding like those people who tell us water fluoridation is deadly because fluoride is a Toxin, used in rat poison etc.
According to the Slate article, you’d have to eat more than 353,000 veggie burgers a day to get to the dose of hexane found safe in rats (and that’s assuming that none of the trace hexane volatilized off during cooking).
Soy burgers sound ecch to me, but not because of Teh Toxins.
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### Author:  [@WarmNPrickly](https://boards.straightdope.com/u/WarmNPrickly)
#### Post date: [February 7, 2011, 4:04pm UTC](https://boards.straightdope.com/t/soy-and-hexane-dangerous/570497/3 "2011-02-07T16:04:00Z")
Hexanes are relatively safe. They are a potential carcinogen but very mild at most. As i understand, its not the hexanes themselves that could cause cancer, but the oxidative breakdown products. Its not something to worry about.
I do wish that they could use diethyl ether instead, but that would be a major safety issue in production. I wonder if ethyl acetate would be non-polar enough. It’s amazing what changes like that would do to an industrial process. Hexanes may be the only thing remotely economical.
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### Author:  [@asterion](https://boards.straightdope.com/u/asterion)
#### Post date: [February 7, 2011, 5:07pm UTC](https://boards.straightdope.com/t/soy-and-hexane-dangerous/570497/4 "2011-02-07T17:07:53Z")
I wonder if they could switch to heptanes instead (while the discovery chemists may use hexanes, the development chemists and the plants use heptane) which has a higher ICH guideline. The permitted daily exposure under ICH guidelines is 2.9 mg/day with a concentration of 290 ppm, while heptane is considered safe at 50 mg/day with a concentration of 5000 ppm.
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### Author:  [@Implicit](https://boards.straightdope.com/u/Implicit)
#### Post date: [February 7, 2011, 5:19pm UTC](https://boards.straightdope.com/t/soy-and-hexane-dangerous/570497/5 "2011-02-07T17:19:27Z")
Do you use vegetable oil? Hexane is used as a solvent to extract canola, sunflower and corn oil too.
You are exposed to a hell of a lot more hexane in gasoline fumes when you fill up your car than you are in food.
> [@](#):
>
> The Cornucopia Institute, an organization formed to support organic and small-farm agriculture, claimed that soy-based foods such as veggie-burgers and certain nutrition bars could potentially be contaminated with hexane. They based their conclusions partially on a small study in Switzerland that looked at (among other things) hexane levels in Swiss cooking oils. However, none of the oils contained more than 0.13 milligrams per kilogram of oil and 88% contained no traces of hexane at all. The institute also sent one sample of soy meal and grits to the FDA for testing. The samples contained residues of hexane (21 and 14 parts per million), that are similar to limits set for hops extracts by the FDA. Since many vegetarian products and nutrition bars use soy protein as an ingredient, the institute fears that non-organic or partially organic brands of these foods might be contaminated with hexane.
>
> Hexane is toxic and exposure to large amounts of it can cause neurological damage. This mostly occurs when workers are exposed to hexane at oil refineries and other places where hexane may escape into the air. Current toxicology research focuses on industrial and airborne exposure to hexane, so it’s not clear how much hexane exposure from foods would be dangerous. However the EPA has estimated that consuming less than 0.06 milligrams hexane per kilogram of body weight is probably safe. For a 200-pound person (97.7 kilograms), that would be about 5.8 milligrams per day. A typical diet, even one with a lot of hexane-extracted vegetable oil, would fall very far short of that. **For example, the oil in the Swiss study with the most hexane contained 0.13 milligram hexane per kilogram of oil, so a 200-pound person would have to consume over 40 gallons of that oil** to even come close to 5.8 milligrams hexane.
[Source](http://nutrition.about.com/od/ahealthykitchen/f/hexane.htm). Bold added by me.
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### Author:  [@ThelmaLou](https://boards.straightdope.com/u/ThelmaLou)
#### Post date: [February 7, 2011, 5:23pm UTC](https://boards.straightdope.com/t/soy-and-hexane-dangerous/570497/6 "2011-02-07T17:23:32Z")
Soy- unfermented soy- by itself is not good. I’m not making this up. Research it yourself. A place to start: [http://www.naturalhealthstrategies.com/dangers-of-soy.html](http://www.naturalhealthstrategies.com/dangers-of-soy.html)
Do note this, however: soy contains natural estrogen, so can be detrimental to a man’s sexual functioning.
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### Author:  [@Peremensoe](https://boards.straightdope.com/u/Peremensoe)
#### Post date: [February 7, 2011, 5:24pm UTC](https://boards.straightdope.com/t/soy-and-hexane-dangerous/570497/7 "2011-02-07T17:24:58Z")
Wouldn’t hexane inhalation, say from the fumes of chemically-extracted cooking oils, be of more concern than ingestion?
ETA: I see **Implicit** has mentioned cooking oils (not _all_ of which are chemically extracted, just all the cheap ones)… but his cite again mentions inhalation only as an industrial hazard, and only considers ingestion for consumers.
And I think most of us know that huffing gasoline fumes isn’t good for the brain.
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### Author:  [@Reply](https://boards.straightdope.com/u/Reply)
#### Post date: [February 7, 2011, 6:13pm UTC](https://boards.straightdope.com/t/soy-and-hexane-dangerous/570497/8 "2011-02-07T18:13:01Z")
> [@ThelmaLou](#):
>
> Soy- unfermented soy- by itself is not good. I’m not making this up. Research it yourself. A place to start: [NameBright - Coming Soon](http://www.naturalhealthstrategies.com/dangers-of-soy.html)
>
> Do note this, however: soy contains natural estrogen, so can be detrimental to a man’s sexual functioning.
I have a little bit in the past, but last I checked the evidence was contradictory and the science rather ambiguous. Has this changed?
The Weston A Price foundation, in particular, has been the subject of criticism over their perspectives and methodology.
Quite honestly, I have no idea what to believe in regards to nutrition science; the more I read the more confused I become.
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### Author:  [@Reply](https://boards.straightdope.com/u/Reply)
#### Post date: [February 7, 2011, 6:33pm UTC](https://boards.straightdope.com/t/soy-and-hexane-dangerous/570497/9 "2011-02-07T18:33:52Z")
> [@asterion](#):
>
> I wonder if they could switch to heptanes instead (while the discovery chemists may use hexanes, the development chemists and the plants use heptane) which has a higher ICH guideline. The permitted daily exposure under ICH guidelines is 2.9 mg/day with a concentration of 290 ppm, while heptane is considered safe at 50 mg/day with a concentration of 5000 ppm.
Sorry, this is a bit over my head. What’s a discovery vs development chemist, what’s ICH, and is concentration significant at all or is it the total daily dosage that matters (i.e., is 50 mg/day worse at 30,000ppm than it is at 5000 ppm?)
> [@Implicit](#):
>
> Do you use vegetable oil? Hexane is used as a solvent to extract canola, sunflower and corn oil too.
>
> You are exposed to a hell of a lot more hexane in gasoline fumes when you fill up your car than you are in food.
> [Source](http://nutrition.about.com/od/ahealthykitchen/f/hexane.htm). Bold added by me.
Good article. Thanks. Gasoline fumes as in while pumping at the station or from exhaust? How much are we talking about here?
> [@spark240](#):
>
> Wouldn’t hexane inhalation, say from the fumes of chemically-extracted cooking oils, be of more concern than ingestion?
>
> ETA: I see **Implicit** has mentioned cooking oils (not _all_ of which are chemically extracted, just all the cheap ones)… but his cite again mentions inhalation only as an industrial hazard, and only considers ingestion for consumers.
>
> And I think most of us know that huffing gasoline fumes isn’t good for the brain.
Is inhalation more dangerous than ingestion?
And I suppose that’s where “expeller-pressed” oils come in to play?
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### Author:  [@ThelmaLou](https://boards.straightdope.com/u/ThelmaLou)
#### Post date: [February 7, 2011, 6:36pm UTC](https://boards.straightdope.com/t/soy-and-hexane-dangerous/570497/10 "2011-02-07T18:36:02Z")
> [@Reply](#):
>
> The Weston A Price foundation, in particular, has been the subject of criticism over their perspectives and methodology.
WHO has been criticizing them… the soy industry? I find the Weston A. Price Foundation and the Price-Pottenger Nutrition Foundation to be quite credible and not at all extremist.
For example, these are the Price-Pottenger Nutritional Guidelines. Even if you don’t agree with every single last one of them (for example, if you’re a vegetarian), they’re a pretty good, sensible, tradition-based set of suggestions.
> [@](#):
>
> These are the Price Pottenger dietary guidelines:
>
> 1. Eat whole, natural foods.
> 2. Eat only foods that will spoil, but eat them before they do.
> 3. Eat naturally raised meat including fish, seafood, poultry, beef, lamb, game, organ meats, and eggs.
> 4. Eat whole, naturally-produced milk products, preferably raw [note: you can’t buy raw dairy products in Texas] and/or fermented, such as whole yogurt, whole cheeses, and fresh and sour cream.
> 5. Use only traditional fats and oils including butter and other animal fats, extra virgin olive oil, expeller expressed sesame and flax oil and the tropical oils, coconut and palm.
> 6. Eat fresh fruits and vegetables, preferably organic, in salads and soups, or lightly steamed with butter.
> 7. Use whole grains and nuts that have been prepared by soaking, sprouting or sour leavening to neutralize phytic acid and other anti-nutrients.
> 8. Include enzyme-enhanced lacto-fermented vegetables, fruits, beverages, and condiments in your diet on a regular basis. [e.g. sauerkraut, kim chee, pickles]
> 9. Prepare homemade meat stocks from the bones of chicken, beef, lamb, or fish and use liberally in soups and sauces.
> 10. Use herb teas and coffee substitutes.
> 11. Use spring water for cooking and baking.
> 12. Use unrefined Celtic sea salt [sometimes called "gray salt’] and a variety of herbs and spices for food interest and appetite stimulation.
> 13. Make your own salad dressing using raw vinegar, extra virgin olive oil, and expeller expressed flax oil.
> 14. Use natural sweeteners in moderation, such as raw honey, maple syrup, dehydrated cane sugar juice, and the herb stevia.
> 15. Use only unpasteurized wine or beer in strict moderation with meals.
> 16. Cook only in stainless steel, cast iron, glass or good quality enamel.
> 17. Use only natural supplements.
> 18. Get plenty of sleep, exercise and natural light.
> 19. Think positive thoughts and minimize stress.
> 20. Practice forgiveness.
>
> Dos and Don’ts
> [ul]
> [li]Don’t eat commercially processed foods such as cookies, cakes, crackers, TV dinners, soft drinks, packaged sauce mixes, etc. [/li][li]Avoid all refined sweeteners such as sugar, dextrose, glucose and high fructose corn syrup. [/li][li]Avoid all white flour, white flour products, and white rice. [/li][li]Avoid all hydrogenated or partially hydrogenated fats and oils. [/li][li]Avoid all vegetable oils made from soy, corn, safflower, canola, and cottonseed. [/li][li]Do not use polyunsaturated oils for cooking, sautéing, or baking. [/li][li]Avoid fried foods. [/li][li]Do not practice strict vegetarianism (veganism); animals products provide vital nutrients not found in plant foods. [/li][li]Avoid products containing protein powders. [/li][li]Avoid pasteurized milk [only pasteurized milk is sold in Texas]; do not consume low-fat milk, skim milk, powdered milk or imitation milk products. [/li][li]Avoid battery-produced eggs and factory farmed meats. [/li][li]Avid highly processed luncheon meats and sausage. [/li][li]Avoid rancid and improperly prepared seeds, nuts and grains found in granolas, quick rise breads, and extruded breakfast cereals, as they block mineral absorption and cause intestinal distress. [/li][li]Avoid canned, sprayed, waxed or irradiated fruits and vegetables. [/li][li]Avoid artificial food additives, especially MSG, hydrolyzed vegetable protein and aspartame, which are neurotoxins. Most soups, sauce and broth mixes and commercial condiments contain MSG even if not so labeled. [/li][li]Avoid caffeine-containing beverages such as coffee, tea and soft drinks. [/li][li]Avoid aluminum-containing foods such as commercial salt, baking powder and antacids. Do not use aluminum cookware of aluminum-containing deodorants. [/li][li]Do not drink fluoridated water. [/li][li]Avoid synthetic vitamins and foods containing them. [/li][li]Do not drink distilled liquors. [/li][li]Do not use a microwave oven.[/li][/ul]
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### Author:  [@Reply](https://boards.straightdope.com/u/Reply)
#### Post date: [February 7, 2011, 6:57pm UTC](https://boards.straightdope.com/t/soy-and-hexane-dangerous/570497/11 "2011-02-07T18:57:45Z")
> [@ThelmaLou](#):
>
> WHO has been criticizing them… the soy industry? I find the Weston A. Price Foundation and the Price-Pottenger Nutrition Foundation to be quite credible and not at all extremist.
There’s a [section on their Wikipedia page](https://secure.wikimedia.org/wikipedia/en/wiki/Weston_a_price_foundation#Criticisms_and_responses).
I haven’t looked into them in detail.
> [@](#):
>
> For example, these are the Price-Pottenger Nutritional Guidelines. Even if you don’t agree with every single last one of them (for example, if you’re a vegetarian), they’re a pretty good, sensible, tradition-based set of suggestions.
Sensible and traditional don’t necessarily equal scientific, healthy, or correct – though I suppose scientific doesn’t necessarily equal healthy or correct either. Some might say – though I’m not sure if I agree with this – that the meat-and-dairy-heavy diet this list advocates may have contributed to the obesity levels in this country. Yes, they advertise plenty of exercise in addition to that, but it’s given nowhere near the same amount of weight. And then a few are just… out there (why steam fruits and veggies with butter? why not use a microwave? why not drink coffee? why use spring water for cooking? why unrefined Celtic sea salt? why no low-fat milk? why no fluoridated water?)
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### Author:  [@Jackmannii](https://boards.straightdope.com/u/Jackmannii)
#### Post date: [February 7, 2011, 7:04pm UTC](https://boards.straightdope.com/t/soy-and-hexane-dangerous/570497/12 "2011-02-07T19:04:04Z")
The Weston Price Foundation has very little credibility among nutritionists and physicians due to extreme and non-evidence based positions on, among other things, soy-based foods and water fluoridation.
The link provided to “Natural Health Strategies” also provides scaremongering about aspartame and aluminum, an example of crank magnetism in action (belief in one form of health nuttiness (in this case, that soy is the Food of Evil), often is linked to the embrace of numerous quack theories\*.
There is [limited and conflicting information](http://www.ncbi.nlm.nih.gov/pubmed/11880591) that soy may have beneficial or detrimental effects in limited subsets of the population (and depending on how much of the diet is soy-based), but there’s very little to base this sort of alarmism on.
Note also that the Weston Price people are gung-ho about us using high-saturated fat/high calorie tropicals oils, which heart experts are very wary of.
> [@ThelmaLou](#):
>
> WHO has been criticizing them… the soy industry?
I can think of one industry that loves Weston Price - the coconut oil producers/exporters. Weston Price’s Mary Enig shows up in numerous industry forums promoting the idea that coconut oil is wonderful for you.
\*We’re just panting to know how using a microwave oven damages your health.
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### Author:  [@cvallaeys](https://boards.straightdope.com/u/cvallaeys)
#### Post date: [February 14, 2011, 3:56pm UTC](https://boards.straightdope.com/t/soy-and-hexane-dangerous/570497/13 "2011-02-14T15:56:02Z")
To answer some of your questions:
n-Hexane is a known neurotoxin according to the Centers for Disease Control and Prevention. Safety studies have been done primarily by forcing rodents to inhale hexane vapors—in a review article of hexane’s safety by the chemical industry, not a single safety study involving primates or ingestion was mentioned.
Soy protein isolate, concentrate and textured vegetable protein are almost universally processed with hexane, although alternative processing methods that do not involve chemical solvents are available. Food processors opt for chemicals like hexane instead of mechanical processes because it’s cheaper and because they can get a little more oil out of the soybean.
Organic soy protein ingredients are never processed with hexane. Federal law strictly prohibits the use of hexane in processing foods that bear the Organic label (including the USDA Organic seal). Only foods with 95%-100% organic ingredients can use the “organic” label on their packaging, and these foods are never processed with hexane. However, products that use the claim “Made with Organic [ingredients]” need only contain 70% organic ingredients, and may use up to 30% non-organic ingredients that can be processed with hexane.
Hexane is the reason why some oils say “expeller-pressed” or “cold-pressed.” It’s their way of letting customers know that the oil was not processed with hexane. Another way of avoiding oil processed with hexane is by choosing organic.
Please note that Cornucopia’s report focused on products that claim to be “natural.” We find it disingenuous for food companies to label themselves as “natural” when the soy protein ingredients they use were immersed in a toxic, highly explosive, petrochemical solvent.
The Cornucopia Institute was founded in 2004 to promote economic-justice for family-scale farmers. It acts as an organic industry watchdog. With over 4,000 members it’s thought to represent more organic farmers than any other organization.
Our work has been covered by the Wall Street Journal, New York Times, Washington Post and National Public Radio in addition to many other news outlets.
Charlotte Vallaeys
Farm and Food Policy Analyst
The Cornucopia Institute
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### Author:  [@Larry\_Mudd](https://boards.straightdope.com/u/Larry_Mudd)
#### Post date: [February 14, 2011, 4:18pm UTC](https://boards.straightdope.com/t/soy-and-hexane-dangerous/570497/14 "2011-02-14T16:18:01Z")
> [@cvallaeys](#):
>
> Our work has been covered by the Wall Street Journal, New York Times, Washington Post and National Public Radio in addition to many other news outlets.
Golly, that means you’re _at least_ as credible as Andrew Wakefield. _swoons_
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### Author:  [@asterion](https://boards.straightdope.com/u/asterion)
#### Post date: [February 14, 2011, 5:26pm UTC](https://boards.straightdope.com/t/soy-and-hexane-dangerous/570497/15 "2011-02-14T17:26:22Z")
> [@Reply](#):
>
> Sorry, this is a bit over my head. What’s a discovery vs development chemist, what’s ICH, and is concentration significant at all or is it the total daily dosage that matters (i.e., is 50 mg/day worse at 30,000ppm than it is at 5000 ppm?)
Sorry, this thread dropped off the page for me. Basically, in the pharmaceutical industry, discovery chemists do the small-scale synthesis of lots of different molecules to test with the goal of selecting a candidate molecule to develop as a potential drug. They generally do the chemistry any way they need to, as fast and (somewhat) dirty is better than cheap and clean for their goals. Development chemists take whatever molecule was selected and work on scaling up and changing, as needed, the route to the target, with the eventual goal to be able to make it in kilogram quantities under GMP conditions and eventual scale-up to a pilot plant or full-blown plant (again, under GMP conditions.) ICH is an international guideline that basically says how much of any given solvent can be in the final product without needing to justify the level to the relevant agency (e.g., FDA). Total daily dosage matters somewhat more than the ppm, as a higher ppm could probably be justified if the overall dose was small enough to keep the total daily dosage under the guideline.
Anyway, my take was from a pharmaceutical perspective. Food chemistry is a whole different world, but I’m still surprised that they can’t make a shift to heptane unless it’s a problem with sourcing the appropriate grade of solvent without an increase in price.
And I would like to ask **cvallaeys** if all isomers of hexane are a known neurotoxin or just n-hexane. I would also like to know if his use of “hexane” in his post is meant to mean n-hexane or an isomeric mixture of hexanes.
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### Author:  [@mnemosyne](https://boards.straightdope.com/u/mnemosyne)
#### Post date: [February 14, 2011, 5:56pm UTC](https://boards.straightdope.com/t/soy-and-hexane-dangerous/570497/16 "2011-02-14T17:56:19Z")
IUPAC would consider “hexane” to refer only to n-hexane, as technically speaking the other isomers are methylated butanes and pentanes.
FWIW, [here](http://www.jtbaker.com/msds/englishhtml/h2381.htm)is an MSDS for a 95% solvent-grade hexane which lists the health hazards for n-hexane specifically. The airborne OSHA limit is 500 ppm. The LD50 in rats by oral ingestion is 28710 mg/kg.