For many years now, I have been an adherent of Doomism, which has two main tenets:
#1: You are doomed. Maybe not today, maybe not tomorrow, maybe not in a way that is final, but inevitably, you will experience doom in a variety of forms over the course of a lifetime.
#2: See #1.
Personal experience suggests adding the following for a universal framework of morality sans metaphysical conceits:
#3: Since final doom could happen any time, the only life strategy that makes sense (absent conclusive proof of an afterlife) is to maximize one’s happiness while one lives. Note that this is not a license to do whatever the fuck you want because if you do, chances are there will be consequences which will make you unhappy and/or bring about some serious doom sooner rather than later, thereby diminishing or curtailing your prospects for future happiness.
#4: There is nothing necessarily for or against giving consideration to other people, causes or concerns when acting, but be aware not everyone does and doing so could leave you vulnerable.
#5: There are limits to the extent one can take responsibility for the actions of others (which is sometimes unavoidable). Failure to observe those limits will likely lead to a measure of doom.
#6: Thou shalt try to avoid making judgements that don’t need to be made, but if you can’t help yourself - and if you’re human, you can’t – try to avoid expressing those judgements in public. Sometimes this is not possible and you may experience a measure of doom because of it.
#7: Thou shalt strive to be patient with and tolerant of others who do not believe as you do, but if they proselytize, it’s okay to subject them and their crackpot beliefs to ridicule and derision.
#8: Moderation in all things, including moderation.
#9: Thou shalt not play near windows nor on stairs.
#10: Thou shalt not go out in public in pajama tops or bottoms.
All of the above stress the vital importance of developing critical thinking skills so one can make reality-based assessments of other people and causes before acting to ensure the best chance of realizing the most enduring prospects for the greatest happiness.