There were at least two times when Southerlyn talks about a friend she had in college (I think it might have been once in high school, once in college), and how no one knew or guessed the person was gay, and the person had problem X. In hindsight, they do sound very much like the kind of thing a closeted person might say when talking about themselves. Then, there is another time when she mentions “my Ex,” in a way that makes it sound like she’s been married, but we never get any more information about the person, including a pronoun. Again, in retrospect, it sounds like the coy way some closeted gay people have of referring to ex-partners.
The purse detail (it was in the episode “The Ring,” which is a great episode) means nothing, because New York is filled with lipstick lesbians who know more about fashion than some of the drag queens.
I actually heard some place that Elisabeth Rohm just slipped that line in there for fun during a first take to try to get Fred Thompson to break character, and he didn’t, and then Wolf ended up liking it and decided to use it in the final cut. That could be a UL, though. But I don’t think the character was intended to be a lesbian all along. It’s still fun to watch reruns through that lens.