They Might Be Giants -- The Musical!

I am envisioning a Hitchcockian suspense scene. The hero has vital information that can halt the career of the villain (I agree that Mr. Horrible isn’t all that villainous. Unlike Dr. Evil. Who is evil. But someone else probably owns the rights to Dr. Evil.)

Anyway, the hero attempts to pass along this vital clue in a nightclub. But he can’t remember it because, “Man, it’s so loud in here.”